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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Do Manganese and Iron in Association Cause Biochemical and Genotoxic Changes in Oreochromis Niloticus (Teleostei: Cichlidae)?

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Author(s):
Passos, Larissa Souza [1, 2] ; Coppo, Gabriel Carvalho [1, 3] ; Pereira, Tatiana Miura [1] ; Teixeira, Barbara Chiste [1] ; Bona, Alliny Magalhaes [1] ; Mercon, Julia [1] ; Lopes, Taciana Onesorge Miranda [1] ; Chippari-Gomes, Adriana Regina [1]
Total Authors: 8
Affiliation:
[1] Vila Velha Univ, Lab Appl Ichthyol, Complex Biopractices, Rua Jose Dantas de Melo 21, BR-29102770 Boa Vista, ES - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Lab Toxins & Nat Algae Prod, Av Prof Lineu Prestes, 580 Bl 17, BR-05508000 Sao Paulo, SP - Brazil
[3] Univ Fed Espirito Santo, Dept Oceanog, Benth Ecol Grp, Av Fernando Ferrari 514, BR-29055460 Vitoria, ES - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Bulletin of Environmental Contamination and Toxicology; OCT 2021.
Web of Science Citations: 0
Abstract

The present study aimed to evaluate the toxicity of the association between Fe and Mn in Oreochromis niloticus through genotoxic (micronucleus test and comet assay) and biochemical (CAT and GST enzymes) assays. The tested treatments were T1 = control group (without metal addition), T2 = 2.60 mg L-1 of Fe + 0.2 mg L-1 of Mn, and T3 = 4.40 mg L-1 of Fe + 3.49 mg L-1 of Mn, during 96-h bioassays. All animals exposed to the metals showed a significant increase in erythrocyte micronucleus frequency and DNA damage. The hepatic GST activity increased two times in animals exposed to T3 compared to the control group. The results indicate that Fe + Mn caused genotoxic and biochemical changes in exposed fish. Therefore, excess metals in ecosystems, even those essential for organisms, can be dangerous for the local biota due to the risk associated with high concentrations of these metals. (AU)

FAPESP's process: 20/00109-6 - Cyanopeptide toxicity assessment in fish for human consumption from artificial ponds
Grantee:Larissa Souza Passos
Support Opportunities: Scholarships in Brazil - Master