| Full text | |
| Author(s): |
Paschoal, Andre Monteiro
[1, 2]
;
Leoni, Renata Ferranti
[2]
;
Foerster, Bernd Uwe
[3]
;
dos Santos, Antonio Carlos
[1]
;
Pontes-Neto, Octavio Marques
[1]
;
Paiva, Fernando Fernandes
[3]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Inbrain, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Inst Fis Sao Carlos, Ave Trabalhador Sao Carlense 400, BR-13566590 Sao Carlos, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE; v. 34, n. 1, SI, p. 119-131, FEB 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Objective Improving the readout for arterial spin labeling with multiple post-labeling delays (multi-PLD ASL) through a flip angle (FA) sweep towards increasing contrast-to-noise ratio for long PLD images. Methods Images were acquired from 20 healthy subjects and 14 patients with severe, asymptomatic carotid artery stenosis (ACAS) in a 3T MRI scanner. Multi-PLD ASL images with conventional and proposed (FA sweep) readouts were acquired. For patients, magnetic resonance angiography was used to validate the multi-PLD ASL results. Perfusion values were calculated for brain regions irrigated by the main cerebral arteries and compared by analysis of variance. Results For healthy subjects, better contrast was obtained for long PLDs when using the proposed multi-PLD method compared to the conventional. For both methods, no hemispheric difference of perfusion was observed. For patients, the proposed method facilitated the observation of delayed tissue perfusion, which was not visible for long PLD using the conventional multi-PLD ASL. Conclusion We successfully assessed brain perfusion of patients with asymptomatic CAS using multi-PLD ASL with FA sweep. We were able to show subtle individual differences. Moreover, prolonged arterial transit time in patients was observed, although they were considered asymptomatic, suggesting that it may not be an adequate term to characterize them. (AU) | |
| FAPESP's process: | 13/23740-0 - Development of an arterial Spin Labeling method for brain perfusion evaluation in patients with delayed arterial transit times |
| Grantee: | Fernando Fernandes Paiva |
| Support Opportunities: | Regular Research Grants |