Overview of chitosan-based nanosystems for prostate cancer therapy

Author(s)

de Araujo, Jennifer Thayanne Cavalcante ^[1] ; Tavares Junior, Alberto Gomes ^[1] ; Di Filippo, Leonardo Delello ^[1] ; Duarte, Jonatas Lobato ^[1] ; Ribeiro, Tais de Cassia ^[1] ; Chorilli, Marlus ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil

• Document type: Journal article
• Source: EUROPEAN POLYMER JOURNAL; v. 160, NOV 5 2021.
• Web of Science Citations: 0

Abstract

Prostate cancer is considered a non-cutaneous cancer and has high prevalence and mortality rates worldwide. Chemotherapeutic agents have several side effects due to non-specific systemic biodistribution. Alternatively, nanocarriers can be an interesting strategy to overcome the limitations and undesirable consequences of conventional treatments. This review aims to explore the properties of chitosan, as well as its pharmaceutical applications in drug delivery nanosystems as a carrier or as a surface moiety for prostate cancer-targeted treatment. The chitosan-based polymeric nanosystems demonstrated good results regarding the delivery of anticancer drugs, improving their release, reducing toxicity, and promoting specific delivery to the tumor cells of prostate cancer. (AU)

• FAPESP's process: 19/19228-8 - Evaluation of curcumin potential incorporated in mesoporous silica nanoparticles dispersed in thermo-responsive hydrogels in the treatment of Alzheimer's Disease
• Grantee: Tais de Cassia Ribeiro
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 19/25125-7 - Nanoemulsions containing terpenes as potentials larvicides and repellents against Aedes aegypti (Linnaeus, 1762)
• Grantee: Jonatas Lobato Duarte
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/18488-3 - Potential evaluation of nanostructured lipid carriers functionalized with bevacizumab for delivery of docetaxel in the treatment of glioblastoma
• Grantee: Leonardo Delello Di Filippo
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 20/06212-3 - Evaluation of the potential of curcumin encapsulated polymeric nanoparticles associated with D-±-tocopheryl polyethylene glycol 1000 succinate functionalized with bevacizumab in the treatment of Prostate Cancer
• Grantee: Jennifer Thayanne Cavalcante de Araújo
• Support Opportunities: Scholarships in Brazil - Doctorate