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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genital mycoplasma infection and spontaneous preterm birth outcome: a prospective cohort study

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Author(s):
Cunha, Gkp [1] ; Bastos, L. B. [1] ; Freitas, S. F. [1] ; Cavalli, R. C. [1] ; Quintana, S. M. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Obstet & Gynaecol, BR-14049900 Ribeirao Preto - Brazil
Total Affiliations: 1
Document type: Journal article
Source: BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY; v. 129, n. 2 OCT 2021.
Web of Science Citations: 2
Abstract

Objective To assess the risk of spontaneous preterm birth (sPTB) associated with genital mycoplasma infection in asymptomatic women. Design Prospective cohort. Setting Public and private health services in Ribeirao Preto, SP, Brazil. Population A cohort of 1349 asymptomatic women with a singleton pregnancy at 20-25 weeks of gestation. Methods Participants completed a sociodemographic and clinical history questionnaire during the prenatal visit and provided cervicovaginal samples for the evaluation of Mycoplasma hominis (Mh), Ureaplasma spp. and bacterial vaginosis (BV). For gestational outcome, information about the delivery was assessed and sPTB was defined as a birth that occurred before 37 weeks of gestation. The association between variables and the risk of sPTB was evaluated using logistic regression analysis to estimate the odds ratios (ORs). Main outcome measures Genital mycoplasma infection and prematurity. Results The prevalence of sPTB and genital mycoplasma was 6.8 and 18%, respectively. The infection was not a risk factor for sPTB (aOR 0.66, 95% CI 0.32-1.35), even when Mh and Ureaplasma spp. were found together (P = 0.83). Pregnant women with genital mycoplasma infections had greater BV (P < 0.0001), but this vaginal microbiota condition was not associated with sPTB (P = 0.35). Regarding the risk factors associated with sPTB, a previous history of sPTB (aOR 12.06, 95% CI 6.21-23.43) and a cervical length of <= 2.5 cm (aOR 3.97, 95% CI 1.67-9.47) were significant. Conclusions Genital mycoplasma infection was not a risk factor for sPTB, even in the presence of other abnormal vaginal microbiota. Tweetable abstract Genital mycoplasma infection was not a risk for sPTB, even when associated with bacterial vaginosis (BV). (AU)

FAPESP's process: 08/53593-0 - Etiological factors of preterm birth and consequences of perinatal factors in child health: birth cohorts in two Brazilian cities (BRISA project)
Grantee:Marco Antonio Barbieri
Support Opportunities: Research Projects - Thematic Grants