ntroduction of SARS-CoV-2 C.37 (WHO VOI lambda) in the Sao Paulo State, Southeast Brazi

Author(s):Show less -

Kashima, Simone ^[1] ; Slavov, Svetoslav N. ^{[2, 1]} ; Giovanetti, Marta ^{[3, 4]} ; Rodrigues, Evandra S. ^[1] ; Patane, Jose S. L. ^[2] ; Viala, Vincent L. ^[2] ; Santos, Elaine V. ^[1] ; Evaristo, Mariane ^[1] ; de Lima, Loyze P. O. ^[2] ; Martins, Antonio J. ^[2] ; dos Santos Barros, Claudia R. ^[2] ; Marqueze, Elaine C. ^[2] ; Garibaldi, Pedro M. M. ^{[5, 6]} ; Ferreira, Natasha N. ^[6] ; Moraes, Glenda R. ^[7] ; Brassaloti, Ricardo A. ^[8] ; Cassano, Raquel L. R. C. ^[8] ; Mariani, Pilar D. S. C. ^[9] ; Kitajima, Joao P. ^[10] ; Schlesinger, David ^[10] ; Bezerra, Rafael S. ^[1] ; Assato, Patricia A. ^[11] ; da Costa, Felipe A. S. ^[11] ; Poleti, Mirele Daiana ^[12] ; Lesbon, Jessika C. C. ^[12] ; Mattos, Elisangela C. ^[12] ; Banho, Cecilia A. ^[13] ; Sacchetto, Livia ^[13] ; Grotto, Rejane M. T. ^{[14, 15]} ; Souza-Neto, Jayme A. ^[15] ; Fonseca, Vagner ^{[3, 16]} ; de Alcantara, Luiz C. J. ^{[3, 4]} ; Nogueira, Mauricio L. ^[13] ; Fukumasu, Heidge ^[12] ; Coutinho, Luiz L. ^[8] ; Borges, Marcos ^{[5, 6]} ; Calado, Rodrigo T. ^{[5, 1]} ; Elias, Maria C. ^[2] ; Sampaio, Sandra C. ^[2] ; Covas, Dimas T. ^{[2, 5, 1]}

Affiliation:Show less -

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Blood Ctr Ribeirao Preto, Ribeirao Preto - Brazil

^[2] Butantan Inst, Sao Paulo - Brazil

^[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Belo Horizonte, MG - Brazil

^[4] Inst Oswaldo Cruz FIOCRUZ, Rio De Janeiro - Brazil

^[5] Univ Sao Paulo, Ribeirao Preto Med Sch, Ribeirao Preto - Brazil

^[6] Serrana State Hosp, Serrana - Brazil

^[7] Epidem Serv, Serrana - Brazil

^[8] Univ Sao Paulo, Ctr Genom Func ESALQ, Piracicaba, SP - Brazil

^[9] NGS Solucoes Genom, Piracicaba, SP - Brazil

^[10] Mendel Anal Genom SA, Sao Paulo - Brazil

^[11] Sao Paulo State Univ UNESP, Sch Agr Sci, Dept Bioproc & Biotechnol, Botucatu, SP - Brazil

^[12] Univ Sao Paulo, Sch Anim Sci & Food Engn, Dept Vet Med, Pirassununga - Brazil

^[13] Med Sch Sao Jose Rio Preto FAMERP, Sao Jose Do Rio Preto, SP - Brazil

^[14] Sao Paulo State Univ UNESP, Sch Agr Sci, Botucatu, SP - Brazil

^[15] Botucatu Med Sch, Clin Hosp, Appl Biotechnol Lab, Mol Biol Lab, Botucato - Brazil

^[16] Minist Saude, Secretaria Vigilancia Saude, Coordenacao Geral Lab Saude Publ, CGLAB SVS MS, Brasilia, DF - Brazil

• Document type: Journal article
• Source: Journal of Medical Virology; v. 94, n. 3 OCT 2021.
• Web of Science Citations: 0

Abstract

The Lambda variants of interest (VOI) (C37/GR/452Q.V1/21G) was initially reported in Lima, Peru but has gained rapid dissemination through other Latin American countries. Nevertheless, the dissemination and molecular epidemiology of the Lambda VOI in Brazil is unknown apart from a single case report. In this respect, we characterized the circulation of the SARS-CoV-2 Lambda VOI (C37/GR/452Q.V1/21G) in Sao Paulo State, Brazil. From March to June 2021, we identified seven Lambda isolates in a set of approximately 8000 newly sequenced genomes of the Network for Pandemic Alert of Emerging SARS-CoV-2 variants from Sao Paulo State. Interestingly, in three of the positive patients, the Lambda VOI infection was probably related to a contact transmission. These individuals were fully vaccinated to COVID-19 and presented mild symptoms. The remaining positive for Lambda VOI individuals showed different levels of COVID-19 symptoms and one of them needed hospitalization (score 5, WHO). In our study, we present a low level of Lambda VOI circulation in the Sao Paulo State. This reinforces the essential role of molecular surveillance for the effective SARS-CoV-2 pandemic response, especially in regard to circulating variants. (AU)

• FAPESP's process: 20/05367-3 - Convalescent donor plasma to treat patients with severe SARS-CoV-2 infection (COVID-19)
• Grantee: Rodrigo do Tocantins Calado de Saloma Rodrigues
• Support Opportunities: Regular Research Grants