Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions

Author(s)

Sibinelli-Sousa, Stephanie ^[1] ; de Araujo-Silva, Andre Luiz ^[1] ; Hespanhol, Julia Takuno ^[1] ; Ethel, Bayer-Santos ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508900 Sao Paulo - Brazil

• Document type: Review article
• Source: FEBS Journal; OCT 2021.
• Web of Science Citations: 0

Abstract

A commensal microbial community is established in the mammalian gut during its development, and these organisms protect the host against pathogenic invaders. The hallmark of noninvasive Salmonella gut infection is the induction of inflammation via effector proteins secreted by the type III secretion system, which modulate host responses to create a new niche in which the pathogen can overcome the colonization resistance imposed by the microbiota. Several studies have shown that endogenous microbes are important to control Salmonella infection by competing for resources. However, there is limited information about antimicrobial mechanisms used by commensals and pathogens during these in vivo disputes for niche control. This review aims to revisit the steps that Salmonella needs to overcome during gut colonization-before and after the induction of inflammation-to achieve an effective infection. We focus on a series of reported and hypothetical antagonistic interbacterial interactions in which both contact-independent and contact-dependent mechanisms might define the outcome of the infection. (AU)

• FAPESP's process: 18/04553-8 - Function of type VI secretion systems of pathogenic bacteria in the interaction with eukaryotic cells
• Grantee: Ethel Bayer Santos
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 19/27644-1 - Contribution of HCPs to the SPI-6 T6SS-dependent pathogenesis of Salmonella Typhimurium
• Grantee: Stephanie Sibinelli de Sousa
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/25316-4 - Function of SPI-6 T6SS and SPI-19 T6SS of Salmonella during competition with the gut microbiota
• Grantee: Julia Takuno Hespanhol
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 17/02178-2 - Function of type VI secretion systems of pathogenic bacteria in the interaction with eukaryotic cells
• Grantee: Ethel Bayer Santos
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 21/02536-1 - Identification of new effectors secreted by the Salmonella T6SS using in silico approaches and functional characterization of a candidate
• Grantee: Andre Luiz de Araújo Silva
• Support Opportunities: Scholarships in Brazil - Master