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Function of SPI-6 T6SS and SPI-19 T6SS of Salmonella during competition with the gut microbiota

Grant number: 18/25316-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2019
Effective date (End): December 31, 2021
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal researcher:Ethel Bayer Santos
Grantee:Julia Takuno Hespanhol
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:17/02178-2 - Function of type VI secretion systems of pathogenic bacteria in the interaction with eukaryotic cells, AP.JP


The genome of Salmonella Typhimurium encodes a type six secretion system (T6SS) within the Salmonella-pathogenicity island 6 (SPI-6). In Salmonella Gallinarum, the T6SS is encoded within SPI-19. Curiously, Salmonella Dublin harbors two T6SSs (SPI-6 and SPI-19). All these systems are important for the establishment of infection in mice and chickens. Recently, it was shown that SPI-6 T6SS from S. Typhimurium is important for competition with bacterial species of the gut microbiota. It is unknown whether SPI-6 T6SS from other Salmonella serotypes or the SPI-19 T6SS would also function during bacterial competition. To clarity these questions, we intend to construct mutant strains for key structural components of T6SSs e test their fitness during competition with Escherichia coli. It is expected at the end of this work to clarify which stereotype and T6SS loci act against bacterial species.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SIBINELLI-SOUSA, STEPHANIE; HESPANHOL, JULIA T.; NICASTRO, GIANLUCCA G.; MATSUYAMA, BRUNO Y.; MESNAGE, STEPHANE; PATEL, ANKUR; DE SOUZA, ROBSON F.; GUZZO, CRISTIANE R.; BAYER-SANTOS, ETHEL. A Family of T6SS Antibacterial Effectors Related to L,D-Transpeptidases Targets the Peptidoglycan. CELL REPORTS, v. 31, n. 12 JUN 23 2020. Web of Science Citations: 0.

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