| Full text | |
| Author(s): |
Total Authors: 4
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| Affiliation: | [1] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Dept Comp & Math, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Univ Fed Goias, Inst Math & Stat, BR-74001970 Goiania, Go - Brazil
[3] Univ Estadual Campinas, Sch Technol, BR-13484332 Limeira, SP - Brazil
Total Affiliations: 3
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| Document type: | Journal article |
| Source: | JOURNAL OF DYNAMICAL AND CONTROL SYSTEMS; OCT 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Oncological therapies usually are applied intermittently, i.e., not continuously over time. In the periods in between, though, the cancer cells are usually left free to grow. This intermittency is a key issue in prostate cancer hormonal therapies based on androgen suppression. Here, we address this treatment modality by analyzing a piecewise smooth vector field approach. In fact, using the PSA (prostate-specific antigen) serum level as a control variable to switch between treatment and no-treatment periods of hormone therapy (androgen withdrawal), by means of typical parameter values, our theoretical analysis supports the idea that intermittent androgen suppression may prevent a prostate cancer relapse for a specific class of patients. (AU) | |
| FAPESP's process: | 17/00883-0 - Piecewise smooth vector fields with applications in biology |
| Grantee: | Tiago de Carvalho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/10450-0 - Piecewise smooth vector fields: Closing Lemmas, shifts and horseshoe dynamics. |
| Grantee: | Tiago de Carvalho |
| Support Opportunities: | Regular Research Grants |