Physical, functional and biochemical features of Nanoskin (R) bacterial cellulose scaffold as a potential carrier for cell transference

Author(s)

Hata Viveiros, Magda Massae ^[1] ; Rainho, Claudia Aparecida ^[1] ; Zamame Ramirez, Jofer Andree ^[1] ; Kaneno, Ramon ^[1] ; Silva, Marcia Guimaraes ^[1] ; Ximenes, Valdecir Farias ^[1] ; de Olyveira, Gabriel Molina ^[2] ; Basmaji, Pierre ^[2] ; Di Girolamo, Nick ^[3] ; Schellini, Silvana Artioli ^[1]

Affiliation

^[1] State Univ Sao Paulo UNESP, Sao Paulo, SP - Brazil

^[2] Innovatecs Biotechnol Res & Dev, Sao Carlos, SP - Brazil

^[3] Univ New South Wales, Sch Med Sci, Sydney, NSW - Australia

• Document type: Journal article
• Source: Materials Letters; v. 308, n. A FEB 1 2022.
• Web of Science Citations: 0

Abstract

We evaluated the feasibility of Nanoskin (R), a bacterial cellulose (BC) nanofiber membrane, as a potential scaffold for cell transference therapy. Nanoskin (R) does not induce lymphocyte proliferation, but it does not kill lymphocytes. Human mesenchymal stem cells (MSCs) and lymphocytes produced significantly elevated amounts of interleukin (IL)-10 (p = 0.0005; p = 0.02) when in contact with Nanoskin (R). In conclusion, the Nanoskin (R) can be a promising biomaterial for use as a cell carrier-scaffold in cell transference therapies. (AU)

• FAPESP's process: 15/10727-0 - Culturing Human Bone Marrow-Derived Mesenchymal Stem Cells on Nanoskin Scaffolds for Ocular Surface Reconstruction.
• Grantee: Silvana Artioli Schellini
• Support Opportunities: Regular Research Grants