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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impact of the activation rate of the hyperpolarization-activated current I-h on the neuronal membrane time constant and synaptic potential duration

Full text
Author(s):
Ceballos, Cesar C. [1, 2] ; Pena, Rodrigo F. O. [1, 3, 4] ; Roque, Antonio C. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Sch Philosophy Sci & Letters Ribeirao Preto, Dept Phys, Ribeirao Preto, SP - Brazil
[2] Oregon Hlth & Sci Univ, Vollum Inst, L474, Portland, OR 97201 - USA
[3] New Jersey Inst Technol, Federated Dept Biol Sci, Newark, NJ 07102 - USA
[4] Rutgers State Univ, Newark, NJ - USA
Total Affiliations: 4
Document type: Journal article
Source: European Physical Journal-Special Topics; v. 230, n. 14-15, p. 2951-2961, OCT 2021.
Web of Science Citations: 1
Abstract

The temporal dynamics of membrane voltage changes in neurons is controlled by ionic currents. These currents are characterized by two main properties: conductance and kinetics. The hyperpolarization-activated current (4) strongly modulates subthreshold potential changes by shortening the excitatory postsynaptic potentials and decreasing their temporal summation. Whereas the shortening of the synaptic potentials caused by the I-h conductance is well understood, the role of the I-h kinetics remains unclear. Here, we use a model of the I-h current model with either fast or slow kinetics to determine its influence on the membrane time constant (tau(m)) of a CA1 pyramidal cell model. Our simulation results show that the I-h with fast kinetics decreases tau(m) and attenuates and shortens the excitatory postsynaptic potentials more than the slow I-h. We conclude that the I-h activation kinetics is able to modulate tau(m) and the temporal properties of excitatory postsynaptic potentials (EPSPs) in CA1 pyramidal cells. To elucidate the mechanisms by which I-h kinetics controls tau(m), we propose a new concept called ``time scaling factor{''}. Our main finding is that the I-h kinetics influences tau(m) by modulating the contribution of the I-h derivative conductance to tau(m). (AU)

FAPESP's process: 11/50151-0 - Dynamical phenomena in complex networks: fundamentals and applications
Grantee:Elbert Einstein Nehrer Macau
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/07699-0 - Research, Innovation and Dissemination Center for Neuromathematics - NeuroMat
Grantee:Oswaldo Baffa Filho
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/25667-8 - Mechanisms of propagation of epileptiform activity in a large-scale cortical model
Grantee:Rodrigo Felipe de Oliveira Pena
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 15/50122-0 - Dynamic phenomena in complex networks: basics and applications
Grantee:Elbert Einstein Nehrer Macau
Support Opportunities: Research Projects - Thematic Grants