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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro bioaccessibility and bioavailability of selenium in agronomic biofortified wheat

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Author(s):
Delaqua, Douglas [1] ; Carnier, Ruan [1] ; Cadore, Solange [2] ; Sanches, Vitor Lacerda [2] ; Berton, Ronaldo Severiano [1] ; Corbi, Fabiana Cristina Andrade [3] ; Coscione, Aline Renee [1]
Total Authors: 7
Affiliation:
[1] Inst Agron Estado Sao Paulo, Ave Barao Itapura 1-481, BR-13020902 Campinas, SP - Brazil
[2] Univ Estadual Campinas UNICAMP, Inst Quim IQ, Rua Josue Castro, S-N Cidade Univ, BR-13083970 Campinas, SP - Brazil
[3] Fac Tecnol FATEC, Tecnol Proc Quim, Av Conego Antonio Roccato, 593 Jardim Santa Monica, BR-13082015 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Food Composition and Analysis; v. 105, JAN 2022.
Web of Science Citations: 0
Abstract

Selenium is an important mineral for humans, and it is often necessary to supplement it in the human diet, not only due to low intake but also mainly because ingested selenium is not effectively absorbed and used by the body in its vital functions. Considering the high global consumption of wheat and the efficiency demonstrated by wheat in biofortification studies, the evaluation of bioaccessible and bioavailable Se fractions in (5, 10 and 20 g ha(-1)) agromomic biofortified wheat grains was performed. For the bioaccessibility experiments, in vitro simulation of digestion in the oral, gastric and intestinal phases was used, whereas bioavailability was evaluated using a cellular model with Caco-2 cells. The bioaccessible fraction of Se enhances with the increase of Se in wheat grains and represented, on average, 63.6-93.8% of the total fraction. However, the bioavailability experiments showed that approximately 65 % of Se is not taken up the cells and that only about 19.6 % is absorbed by the human body, for all the doses investigated. The results of this study show that the nutritional contents of biofortified foods should take into account the fractions absorbed by the body and not only the total contents as established by law. (AU)

FAPESP's process: 08/57808-1 - National Institute of Advanced Analytical Science and Technology
Grantee:Celio Pasquini
Support Opportunities: Research Projects - Thematic Grants