| Full text | |
| Author(s): |
Rozza, Ariane Leite
[1]
;
Beserra, Fernando Pereira
[1]
;
Vieira, Ana Julia
[1]
;
Oliveira de Souza, Eduardo
[1]
;
Hussni, Carlos Alberto
[2]
;
Martinez, Emanuel Ricardo Monteiro
[1]
;
Nobrega, Rafael Henrique
[1]
;
Pellizzon, Claudia Helena
[1]
Total Authors: 8
|
| Affiliation: | [1] Sao Paulo State Univ UNESP, Dept Struct & Funct Biol, Dr Antonio Celso Zanin St 250, BR-18618689 Botucatu, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Surg & Vet Anesthesiol, Dr Walter M Correa St, BR-18618689 Botucatu, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | PHARMACEUTICS; v. 13, n. 11 NOV 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Wound healing involves inflammatory, proliferative, and remodeling phases, in which various cells and chemical intermediates are involved. This study aimed to investigate the skin wound healing potential of menthol, as well as the mechanisms involved in its effect, after 3, 7, or 14 days of treatment, according to the phases of wound healing. Skin wound was performed in the back of Wistar rats, which were topically treated with vehicle cream; collagenase-based cream (1.2 U/g); or menthol-based cream at 0.25%, 0.5%, or 1.0% over 3, 7, or 14 days. Menthol cream at 0.5% accelerated the healing right from the inflammatory phase (3 days) by decreasing mRNA expression of inflammatory cytokines TNF-alpha and Il-6. At the proliferative phase (7 days), menthol 0.5% increased the activity of antioxidant enzymes SOD, GR, and GPx, as well as the level of GSH, in addition to decreasing the levels of inflammatory cytokines TNF-alpha, IL-6, and IL-1 beta and augmenting mRNA expression for Ki-67, a marker of cellular proliferation. At the remodeling phase (14 days), levels of inflammatory cytokines were decreased, and the level of Il-10 and its mRNA expression were increased in the menthol 0.5% group. Menthol presented skin wound healing activity by modulating the antioxidant system of the cells and the inflammatory response, in addition to stimulating epithelialization. (AU) | |
| FAPESP's process: | 13/23340-1 - Skin healing under treatment with monoterpene (menthol) and triterpene (Lupeol) in experimental model |
| Grantee: | Claudia Helena Pellizzon |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/22202-4 - Use of a menthol-based cream in the wound healing |
| Grantee: | Ariane Leite Rozza |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 15/06636-0 - Antioxidant and anti-inflammatory activities of menthol in skin wound healing |
| Grantee: | Eduardo Oliveira de Souza |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 16/13307-5 - Physiological mechanisms involved in skin wound healing after treatment with menthol-based cream in diabetic and non-diabetic rats |
| Grantee: | Ariane Leite Rozza |
| Support Opportunities: | Regular Research Grants |