Association between fibroblast growth factor 23 and functional capacity among independent elderly individuals

Author(s)

Quirino Araujo, Lara Miguel ^[1] ; do Prado Moreira, Patricia Ferreira ^[1] ; Almada Filho, Clineu de Mello ^[1] ; de Araujo, Luciano Vieira ^[2] ; Costa, Aline Granja ^[3] ; Cintra Sesso, Ricardo de Castro ^[1] ; Bilezikian, John P. ^[3] ; Lazaretti-Castro, Marise ^[1] ; Cendoroglo, Maysa Seabra ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Escola Artes Ciencias & Humanidades, Sao Paulo, SP - Brazil

^[3] Columbia Univ, Coll Phys & Surg, Dept Endocrinol, Nova Lorque, NY - USA

• Document type: Journal article
• Source: Einstein (São Paulo); v. 19, 2021.
• Web of Science Citations: 0

Abstract

Objective: To examine the association of between serum fibroblast growth factor 23 and the functional capacity among independent individuals, aged 80 or older. Methods: The functional capacity of 144 elderly was assessed by Instrumental Activities of Daily Living, cognitive tests, handgrip strength and the timed ability to rise from a chair and sit down five times. Fibroblast growth factor 23 was measured using an ELISA assay. Results: Participants in the lowest fibroblast growth factor 23 tertile had the highest mean +/- standard deviation estimated glomerular filtration rate, the highest mean hemoglobin level, the lowest average number of diseases and the lowest number of medications used. In participants with the estimated glomerular filtration rate >45mL/minute/1.73m(2), mean fibroblast growth factor 23 level was higher in those with 25(OH) vitamin D <20ng/mL than in those with 25(OH) vitamin D >= 20ng/mL (75.6RU/mL +/- 42.8 versus 68.5RU/mL +/- 41.7; p<0.001). There was an increase in the mean serum cystatin C (from 1.3mg/mL +/- 0.3 to 1.5mg/mL +/- 0.3 to 1.7mg/mL +/- 0.4) as function of higher fibroblast growth factor 23 tertile (p<0.001). Fibroblast growth factor 23 levels were not significantly associated with capacity in physical or cognitive tests. Conclusion: In independent community-dwelling elderly, aged >= 80 years, fibroblast growth factor 23 was associated with aged-related comorbidities and renal function but not with functional capacity. (AU)

• FAPESP's process: 11/12753-8 - Renal function markers, vitamin D and functional capacity in elderly
• Grantee: Maysa Seabra Cendoroglo
• Support Opportunities: Regular Research Grants