Draft genome sequence of the cyanobacterium Sphaerospermopsis aphanizomenoides BCCUSP55 from the Brazilian semiarid region reveals potential for anti-cancer applications

Author(s)

Lorenzi, Adriana Sturion ^{[1, 2]} ; Bonatelli, Maria Leticia ^[3] ; Varani, Alessandro M. ^[4] ; Quecine, Maria Carolina ^[3] ; Bittencourt-Oliveira, Maria do Carmo ^[1]

Affiliation

^[1] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Biol Sci, Piracicaba, SP - Brazil

^[2] Univ Brasilia UnB, Inst Biol Sci, Dept Cellular Biol, Brasilia, DF - Brazil

^[3] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Genet, Piracicaba, SP - Brazil

^[4] Sao Paulo State Univ, Sch Agr & Vet Sci, Jaboticabal, SP - Brazil

• Document type: Journal article
• Source: Archives of Microbiology; v. 204, n. 1 JAN 2022.
• Web of Science Citations: 0

Abstract

Sphaerospermopsis aphanizomenoides is a filamentous nitrogen-fixing and bloom-forming cyanobacterium, which biomass can fertilize natural water with nutrients, especially through nitrogen fixation. The Sphaerospermopsis aphanizomenoides strain BCCUSP55 was previously isolated from a water supply reservoir in the Brazilian semiarid region, and its draft genome assembly coupled with the gene contents are reported here. The obtained BCCUSP55 draft genome comprised 254 scaffolds with a genome size estimated of 6,096,273 bp. In addition, it has 5250 predicted coding sequences (CDS) and the G + C content is 38.5%. Further, the BCCUSP55 draft genome presented the putative nocuolin A gene complete cluster, a natural oxadiazine that triggers apoptosis in human cancer cells. Thus, our results contribute to extend the knowledge on the genus Sphaerospermopsis and reveal its biotechnological potential. (AU)

• FAPESP's process: 13/15296-2 - Comparative metagenomics of cyanobacterial blooms in freshwater reservoirs from Pernambuco State
• Grantee: Adriana Sturion Lorenzi
• Support Opportunities: Research Grants - Young Investigators Grants