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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients

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Author(s):
Tahira, Ana C. [1] ; Verjovski-Almeida, Sergio [1, 2] ; Ferreira, Sergio T. [3, 4]
Total Authors: 3
Affiliation:
[1] Inst Butantan, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Quim, BR-05508900 Sao Paulo, SP - Brazil
[3] Univ Fed Rio de Janeiro, Inst Biophys Carlos Chagas Filho, BR-21944590 Rio De Janeiro, RJ - Brazil
[4] Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, Rio De Janeiro - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ALZHEIMERS & DEMENTIA; v. 17, n. 11, p. 1818-1831, NOV 2021.
Web of Science Citations: 3
Abstract

Introduction Dementia has been associated with COVID-19 prevalence, but whether this reflects higher infection, older age of patients, or disease severity remains unclear. Methods We investigated a cohort of 12,863 UK Biobank community-dwelling individuals > 65 years old (1814 individuals >= 80 years old) tested for COVID-19. Individuals were stratified by age to account for age as a confounder. Risk factors were analyzed for COVID-19-positive diagnosis, hospitalization, and death. Results All-cause dementia, Alzheimer's disease (AD), and Parkinson's disease (PD) were associated with COVID-19-positive diagnosis, and all-cause dementia and AD remained associated in individuals >= 80 years old. All-cause dementia, AD, or PD were not risk factors for overall hospitalization, but increased the risk of hospitalization of COVID-19 patients. All-cause dementia and AD increased the risk of COVID-19-related death, and all-cause dementia was uniquely associated with increased death in >= 80-year-old patients. Discussion All-cause dementia and AD are age-independent risk factors for disease severity and death in COVID-19. (AU)

FAPESP's process: 18/23693-5 - Mechanisms of action of long non-coding RNAs involved with gene activation programs in eukaryotes
Grantee:Sergio Verjovski Almeida
Support Opportunities: Research Projects - Thematic Grants