Evaluation of cytokine profile in the different phases of the autologous hematopoietic stem cell transplantation in patients with multiple myeloma

Author(s)

Callera, AlexandraFernandes ^[1] ; Callera, Fernando ^[2] ; Brito, Aurileia Aparecida ^[3] ; Oliveira, Carlos Rocha ^{[4, 5]} ; Lacerda Bachi, Andre Luis ^[6] ; Vieira, Rodolfo P. ^{[1, 7, 8, 9]}

Affiliation

^[1] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, SP - Brazil

^[2] Ctr Hematol Vale, Sao Paulo, SP - Brazil

^[3] Nove de Julho Univ, Sao Paulo, SP - Brazil

^[4] Anhembi Morumbi Univ, Sao Jose Dos Campos, SP - Brazil

^[5] Univ Fed Sao Paulo, Postgrad Program Biomed Engn, Sao Jose Dos Campos, SP - Brazil

^[6] Univ Santo Amaro, Sao Paulo, SP - Brazil

^[7] Univ Brasil, Postgrad Program Bioengn, Sao Paulo, SP - Brazil

^[8] Univ Fed Sao Paulo, Postgrad Program Sci Human Movement & Rehabil, Santos, SP - Brazil

^[9] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: TRANSPLANT IMMUNOLOGY; v. 70, FEB 2022.
• Web of Science Citations: 0

Abstract

Background: The autologous hematopoietic stem cell transplantation (ASCT) is of fundamental importance in the treatment of patients with multiple myeloma (MM). Nevertheless, due to its toxicity, it decreases the number of bone marrow cells available, altering the cell interactions and causing an imbalance between pro- and antiinflammatory cytokines. Methods: Thus, we determined the serum levels of pro- and anti-inflammatory cytokines in samples of patients with MM obtained from the different phases of ASCT. Results: In summary, the cytokines levels varied considering the different phases of ASCT. The levels of IL-1ra tend to increase in the post-apheresis period suggesting an anti-inflammatory role induced by the apheresis process. A response characterized by the increase in the concentrations of IL-5 and IL-8 was observed in the postconditioning bone marrow aplasia phase. The rise in IL-5 levels was not correlated with any clinical or laboratory event in this framework; IL-8 was associated with positive blood cultures and seems to have an effect against microbial agents. The increase in the levels of IL-10 and IL-12 suggests a possible regulatory effect of the inflammatory response in the period of bone marrow recovery and IL-12 seems to be inversely associated with the presence of minimal residual disease. Conclusions: Apheresis process seems to induce an anti-inflammatory response, followed by a pro-inflammatory response and a stimulus for granulocytes differentiation. (AU)

• FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
• Grantee: Rodolfo de Paula Vieira
• Support Opportunities: Research Grants - Young Investigators Grants