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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

t takes time to heal a broken heart: ventricular plasticity improves heart performance after myocardial infarction in rainbow trout, Oncorhynchus mykis

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Author(s):
Zena, Lucas A. [1, 2] ; Ekstrom, Andreas [1] ; Grans, Albin [3] ; Olsson, Catharina [1] ; Axelsson, Michael [1] ; Sundh, Henrik [1] ; Sandblom, Erik [1]
Total Authors: 7
Affiliation:
[1] Univ Gothenburg, Dept Biol & Environm Sci, S-40530 Gothenburg - Sweden
[2] Univ Sao Paulo, Inst Biosci, Dept Physiol, BR-05508090 Sao Paulo - Brazil
[3] Swedish Univ Agr Sci, Dept Anim Environm & Hlth, S-40530 Gothenburg - Sweden
Total Affiliations: 3
Document type: Journal article
Source: Journal of Experimental Biology; v. 224, n. 23 DEC 2021.
Web of Science Citations: 1
Abstract

Coronary arteriosclerosis is a common feature of both wild and farmed salmonid fishes and may be linked to stress-induced cardiac pathologies. Yet, the plasticity and capacity for long-term myocardial restructuring and recovery following a restriction in coronary blood supply are unknown. Here, we analyzed the consequences of acute (3 days) and chronic ( from 33 to 62 days) coronary occlusion (i.e. coronary artery ligation) on cardiac morphological characteristics and in vivo function in juvenile rainbow trout, Oncorhynchus mykiss. Acute coronary artery occlusion resulted in elevated resting heart rate and decreased inter-beat variability, which are both markers of autonomic dysfunction following acute myocardial ischemia, along with severely reduced heart rate scope (maximum-resting heart rate) relative to sham-operated trout. We also observed a loss of myocardial interstitial collagen and compact myocardium. Following long-term coronary artery ligation, resting heart rate and heart rate scope normalized relative to sham-operated trout. Moreover, a distinct fibrous collagen layer separating the compact myocardium into two layers had formed. This may contribute to maintain ventricular integrity across the cardiac cycle or, alternatively, demark a region of the compact myocardium that continues to receive oxygen from the luminal venous blood. Taken together, we demonstrate that rainbow trout may cope with the aversive effects caused by coronary artery obstruction through plastic ventricular remodeling, which, at least in part, restores cardiac performance and myocardium oxygenation. (AU)

FAPESP's process: 17/01652-2 - Seasonal physiology in the tegu lizard Salvator merianae: an animal model for assessing physiological functions in a dynamic and changing environment
Grantee:Lucas Aparecido Zena
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/12311-7 - Physiological plasticity and consequences of global change in ectothermic organisms
Grantee:Lucas Aparecido Zena
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor