| Full text | |
| Author(s): |
Vilas-Boas, Eloisa Aparecida
[1, 2]
;
Almeida, Davidson Correa
[3]
;
Roma, Leticia Prates
[4]
;
Ortis, Fernanda
[3]
;
Carpinelli, Angelo Rafael
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Chem, Dept Biochem, BR-05508900 Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508000 Sao Paulo - Brazil
[4] Saarland Univ, Dept Biophys, Ctr Human & Mol Biol ZHMB, D-66424 Homburg - Germany
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | CELLS; v. 10, n. 12 DEC 2021. |
| Web of Science Citations: | 1 |
| Abstract | |
A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity, which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus increases plasma levels of fatty acids (FAs), especially saturated ones, which were shown to negatively impact pancreatic beta-cell function and survival in a process called lipotoxicity. Lipotoxicity in beta-cells activates different stress pathways, culminating in beta-cells dysfunction and death. Among all stresses, endoplasmic reticulum (ER) stress and oxidative stress have been shown to be strongly correlated. One main source of oxidative stress in pancreatic beta-cells appears to be the reactive oxygen species producer NADPH oxidase (NOX) enzyme, which has a role in the glucose-stimulated insulin secretion and in the beta-cell demise during both T1 and T2D. In this review, we focus on the acute and chronic effects of FAs and the lipotoxicity-induced beta-cell failure during T2D development, with special emphasis on the oxidative stress induced by NOX, the ER stress, and the crosstalk between NOX and ER stress. (AU) | |
| FAPESP's process: | 17/26339-5 - Involvement of NADPH oxidase isoforms in the dysfunction of insulin secreting cells exposed to pro-inflammatory cytokines |
| Grantee: | Angelo Rafael Carpinelli |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/04580-2 - Study of pancreatic beta cell demise: role of NF-kB, HNF4a and IL6 in the Diabetes mellitus development |
| Grantee: | Fernanda Ortis |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/26062-9 - Evaluation of the transcriptional factor HNF4± in beta cell function, viability and differentiation state, in conditions that can lead to development of Diabetes Mellitus |
| Grantee: | Fernanda Ortis |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis |
| Grantee: | Marco Aurelio Zezzi Arruda |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 20/06184-0 - Characterization of the expression of NADPH oxidase isoforms in pancreatic beta cells and its modulation by proinflammatory cytokines |
| Grantee: | Angelo Rafael Carpinelli |
| Support Opportunities: | Regular Research Grants |