Sleep duration as an independent factor associated with vitamin D levels in the EPISONO cohort

Author(s)

de Oliveira, Daniela Leite ^[1] ; Dokkedal-Silva, Vinicius ^[1] ; Fernandes, Guilherme Luiz ^[1] ; Kim, Lenise Jihe ^[1] ; Tufik, Sergio ^[1] ; Andersen, Monica Levy ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF CLINICAL SLEEP MEDICINE; v. 17, n. 12, p. 2439-2449, DEC 1 2021.
• Web of Science Citations: 0

Abstract

Study objectives: Obstructive sleep apnea and short sleep duration have been separately associated with inadequate serum 25-hydroxyvitamin D {[}25(OH)D] levels. However, whether these 2 factors may concurrently influence 25(OH)D in the general population is unknown. We hypothesized that both obstructive sleep apnea and short sleep duration would be independently associated with lower concentrations of 25(OH)D in a sex-dependent manner. Methods: In this cross-sectional study, 712 individuals, part of the prospective EPISONO cohort (Brazil), underwent polysomnography, answered sleep questionnaires, and had their blood collected for serum 25(OH)D quantification. Results: Individuals with a sleep duration of < 6 hours had 2-fold increased odds of 25(OH)D < 20 ng/mL compared with those who reported 6 or more hours of sleep, even after adjusting for confounding factors. Subset sex analysis revealed that men with a sleep duration of < 6 hours had 4-fold increased odds of 25(OH)D < 20 ng/mL. In women, short sleep duration was not associated with lower 25(OH)D levels. The presence of obstructive sleep apnea (as classified according to the individual's apnea-hypopnea index) was not independently related to 25(OH)D concentrations in men or women. Sleep parameters, including sleep latency and sleep efficiency, had no association with 25(OH)D < 20 ng/mL. Conclusions: Short sleep, but not apnea-hypopnea index, was an independent factor associated with low 25(OH)D serum levels in men, but not in women. Apnea-hypopnea index scores were not associated with 25(OH)D levels in either sex. These results raise the possibility of investigating sex-specific characteristics, such as gonadal hormone regulation, and re-evaluating obstructive events by classifying them in mild, moderate, and severe obstructive sleep apnea. (AU)

• FAPESP's process: 16/02205-7 - Acute and chronic sleep deprivation effects in the regulatory pathway of vitamin D in an animal model
• Grantee: Daniela Leite de Oliveira
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/19136-5 - Effects of excessive daytime sleepiness or insomnia associated with obstructive sleep apnea on the cardiovascular risk: a prospective longitudinal population-based study
• Grantee: Lenise Jihe Kim
• Support Opportunities: Scholarships in Brazil - Doctorate