Respiratory disorders of Parkinson's disease

Author(s)

Aquino, Yasmin C. ^[1] ; Cabral, Lais M. ^[1] ; Miranda, Nicole C. ^[1] ; Naccarato, Monique C. ^[1] ; Falquetto, Barbara ^[1] ; Moreira, Thiago S. ^[2] ; Takakura, Ana C. ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Pharmacol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Physiol & Biophys, Sao Paulo - Brazil

• Document type: Review article
• Source: Journal of Neurophysiology; v. 127, n. 1, p. 1-15, JAN 2022.
• Web of Science Citations: 0

Abstract

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, mainly affecting people over 60 yr of age. Patients develop both classic symptoms (tremors, muscle rigidity, bradykinesia, and postural instability) and nonclassical symptoms (orthostatic hypotension, neuropsychiatric deficiency, sleep disturbances, and respiratory disorders). Thus, patients with PD can have a significantly impaired quality of life, especially when they do not have multimodality therapeutic follow-up. The respiratory alterations associated with this syndrome are the main cause of mortality in PD. They can be classified as peripheral when caused by disorders of the upper airways or muscles involved in breathing and as central when triggered by functional deficits of important neurons located in the brainstem involved in respiratory control. Currently, there is little research describing these disorders, and therefore, there is no well-established knowledge about the subject, making the treatment of patients with respiratory symptoms difficult. In this review, the history of the pathology and data about the respiratory changes in PD obtained thus far will be addressed. (AU)

• FAPESP's process: 15/23376-1 - Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity
• Grantee: Thiago dos Santos Moreira
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 20/16320-8 - Investigation of the existence of anatomical projections from substantia nigra to pre-Bötzinger complex
• Grantee: Yasmin Cestari Aquino
• Support type: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/00065-1 - Oxidative stress in respiratory control of Parkinson Disease animal model
• Grantee: Bárbara Falquetto
• Support type: Research Grants - Young Investigators Grants
• FAPESP's process: 19/01236-4 - Effects of pharmacological and non-pharmacological treatments on respiratory changes observed in a murine model of Parkinson's disease
• Grantee: Ana Carolina Thomaz Takakura
• Support type: Regular Research Grants