lebsiella-induced infections in domestic species: a case-series study in 697 animals (1997-2019

Author(s):Show less -

Ribeiro, Marcio Garcia ^{[1, 2]} ; Cordeiro de Morais, Amanda Bonalume ^[2] ; Alves, Ana Carolina ^[2] ; Daza Bolanos, Carmen Alicia ^[3] ; de Paula, Carolina Lechinski ^[2] ; Ramos Portilho, Fabio Vinicius ^[2] ; de Nardi Junior, Geraldo ^[4] ; Batista Lara, Gustavo Henrique ^[2] ; Araujo Martins, Lorrayne de Souza ^[2] ; Moraes, Lucieny Sierra ^[2] ; Risseti, Rafaela Mastrangelo ^[2] ; Guerra, Simony Trevizan ^[2] ; Bello, Thais Spessotto ^[2] ; Siqueira, Amanda Keller ^[2] ; Bertolini, Amanda Bezerra ^[2] ; Rodrigues, Carolina Aparecida ^[2] ; Paschoal, Natalia Rodrigues ^[2] ; de Almeida, Beatriz Oliveira ^[2] ; Paganini Listoni, Fernando Jose ^[2] ; Garcia Sanchez, Luisa Fernanda ^[2] ; Paes, Antonio Carlos ^[2]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, BR-18618681 Botucatu, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Anim Prod & Prevent Vet Med, Botucatu, SP - Brazil

^[3] Antonio Narino Univ, Fac Vet Med & Anim Sci, Dept Vet Med, Bogota - Colombia

^[4] FATEC, Technol Fac, Botucatu, SP - Brazil

• Document type: Journal article
• Source: Brazilian Journal of Microbiology; v. 53, n. 1 JAN 2022.
• Web of Science Citations: 0

Abstract

Klebsiella species, particularly K. pneumoniae, are well-known opportunistic enterobacteria related to complexity of clinical infections in humans and animals, commonly refractory to conventional therapy. The domestic animals may represent a source of the pathogenic and multidrug-resistant Klebsiella species to humans. Nevertheless, most studies involving Klebsiella-induced infections in domestic animals are restricted to case reports or outbreaks. We retrospectively investigated selected epidemiological data, clinical aspects, and in vitro susceptibility pattern of 697 non-repetitive Klebsiella infections in livestock and companion species (1997-2019). The isolates were obtained from different clinical disorders from dogs (n=393), cattle (n = 149), horses (n = 98), cats (n = 27), pigs (n= 22), sheep (n = 5), goats (n = 2), and buffalo (n =1), except four isolates from subclinical bovine mastitis. Urinary (223/697 = 32%), enteric (117/697 = 16.8%), mammary (85/697 =12.2%), reproductive (85/697 =12.2%), and respiratory disorders (67/697 = 9.6%) were the most common clinical manifestations. Other miscellaneous clinical pictures (116/697 =16.6%) included abscesses, otitis, hepatitis, conjunctivitis, pyodermitis, sepsis, and encephalitis. Norfloxacin (183/245 =74.7%) and gentamicin (226/330 = 68.5%) were the most effective antimicrobials. High in vitro resistance of the isolates was seen to ampicillin (326/355 = 91.8%), amoxicillin/clavulanic acid (25/62=40.3%), and trimethoprim/sulfamethoxazole (100/252 =39.7), and multidrug resistance to >= 3 classes of antimicrobials was found in 20.4% (142/697) isolates. Wide variety of clinical manifestations of Klebsiella-induced infections was observed, with a predominance of urinary, enteric, mammary, reproductive, and respiratory tract disorders, reinforcing opportunistic behavior of agent. Poor in vitro efficacy was observed to some conventional antimicrobials and similar to 20% of isolates exhibited resistance pattern, reinforcing the need for proper use of drugs on therapy approaches in domestic animals to avoid multidrug-resistant bacteria, an emergent global concern. (AU)

• FAPESP's process: 15/19688-8 - E. coli, Klebsiella pnemoniae and Enterococcus spp: impact of virulence factors in bovine mastitis and public health concern
• Grantee: Helio Langoni
• Support Opportunities: Research Projects - Thematic Grants