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E. coli, Klebsiella pnemoniae and Enterococcus spp: impact of virulence factors in bovine mastitis and public health concern

Grant number: 15/19688-8
Support Opportunities:Research Projects - Thematic Grants
Duration: April 01, 2017 - March 31, 2022
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
Principal Investigator:Helio Langoni
Grantee:Helio Langoni
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Pesquisadores principais:
Marcio Garcia Ribeiro ; Vera Lúcia Mores Rall
Associated researchers:Domingos da Silva Leite ; José Carlos de Figueiredo Pantoja ; Rodrigo Tavanelli Hernandes ; Simone Baldini Lucheis
Associated scholarship(s):20/04598-1 - Speciation of enterobacteria and other Gram-negative bacteria less frequent in clinical bovine mastitis cases diagnosed by mass spectrometry, BP.IC
19/01862-2 - Mastitis epidemiology in the post-partum period and its impact on the lactation of dairy cows, BP.IC
18/09086-9 - Differentiation of species of Mycoplasma spp. isolated from cases of clinical mastitis cases and expansion tanks, BP.MS
+ associated scholarships 18/22101-7 - E. coli, Klebsiella pneumoniae and Enterococcus spp.: impact of virulence factors in bovine mastitis and public health concern, BP.TT
18/17354-3 - Multidrug resistance and identification of genes associated with carbapenemases production in Klebsiella pneumoniae isolated from clinical and subclinical bovine mastitis, BP.IC
17/08823-7 - Identification of Enterococcus spp. by proteomics and vancomycin resistance gene screening in isolates of cows with Mastitis and in milk from expansion tanks, BP.PD
17/08102-8 - Characterization, molecular profile, virulence and multidrug resistance factors in strains of Escherichia coli isolated from Bovine Mastitis with different scores, BP.DD
17/07246-6 - Molecular characterization, sensitivity profile and biofilm production from Escherichia coli isolated from bulk tanks, BP.DD - associated scholarships

Abstract

Mastitis is a multifactorial disease caused by approximately 140 microorganisms, related to infectious or environmental origin, with varying degrees of infectivity. In addition to the economic losses of disease, both for producers and for the dairy industry by lower industrial output and lower shelf period of dairy products, the impact of these agents in the public health context, as many of the pathogens involved in its etiology is notorious zoonotic agents, toxins producers, enterotoxin and other virulence factors, causing serious infections and food poisoning outbreaks. Control programs are essential to reduce the incidence of mastitis including environmental origin, aiming to better quality of milk offered for consumption, and improve their production. There is much to study in search of information about the genotypic and phenotypic characterization of pathogens involved in intramammary infection and virulence factors, and research of its triggering genes, cytokine profile as virulence markers and multiple drug resistance of these pathogens. The present study aims to investigate cases of clinical mastitis caused by Escherichia coli, Klebisiella pneumoniae and Enterococcus spp., isolates from clinical samples and milk of bulk tanks in ten farms of high production in the state São Paulo and Minas Gerais, obtained every three months during the period of 18 months. It is expected to deepen the knowledge in cases of environmental mastitis caused by these pathogens, especially in the matters of virulence, multidrug resistance to antimicrobials and immunopathology, enabling strategies for prevention, control and consequences for public health. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ORSI, HENRIQUE; GUIMARAES, FELIPE F.; LEITE, DOMINGOS S.; GUERRA, SIMONY T.; JOAQUIM, SAMEA F.; PANTOJA, JOSE C. F.; HERNANDES, RODRIGO T.; LUCHEIS, SIMONE B.; RIBEIRO, MARCIO G.; LANGONI, HELIO; et al. Characterization of mammary pathogenic Escherichia coli reveals the diversity of Escherichia coli isolates associated with bovine clinical mastitis in Brazil. JOURNAL OF DAIRY SCIENCE, v. 106, n. 2, p. 11-pg., . (15/19688-8)
JUNQUEIRA, NATHALIA BRANCATO; SALINA, ANELISE; OLIVEIRA, GABRIELA CAPRIOGLI; METTIFOGO, ELENA; JOAQUIM, SAMEA FERNANDES; GUIMARAES, FELIPE FREITAS; DALANEZI, FELIPE MORALES; LANGONI, HELIO. Detection of clinical bovine mastitis caused byMycoplasma bovisin Brazil. JOURNAL OF DAIRY RESEARCH, v. 87, n. 3, p. 306-308, . (15/19688-8)
DALANEZI, F. M.; JOAQUIM, S. F.; GUIMARAES, F. F.; GUERRA, S. T.; LOPES, B. C.; SCHMIDT, E. M. S.; CERRI, R. L. A.; LANGONI, H.. Influence of pathogens causing clinical mastitis on reproductive variables of dairy cows. JOURNAL OF DAIRY SCIENCE, v. 103, n. 4, p. 3648-3655, . (15/26055-1, 15/19688-8)
RIBEIRO, MARCIO GARCIA; CORDEIRO DE MORAIS, AMANDA BONALUME; ALVES, ANA CAROLINA; DAZA BOLANOS, CARMEN ALICIA; DE PAULA, CAROLINA LECHINSKI; RAMOS PORTILHO, FABIO VINICIUS; DE NARDI JUNIOR, GERALDO; BATISTA LARA, GUSTAVO HENRIQUE; ARAUJO MARTINS, LORRAYNE DE SOUZA; MORAES, LUCIENY SIERRA; et al. lebsiella-induced infections in domestic species: a case-series study in 697 animals (1997-2019. Brazilian Journal of Microbiology, v. 53, n. 1, . (15/19688-8)
ALVES, TAILA DOS SANTOS; ROSA, VINICIUS SANCHES; LEITE, DOMINGOS DA SILVA; GUERRA, SIMONY TREVIZAN; JOAQUIM, SAMEA FERNANDES; GUIMARAES, FELIPE FREITAS; PANTOJA, JOSE CARLOS DE FIGUEIREDO; LUCHEIS, SIMONI BALDINI; RALL, VERA LUCIA MORES; HERNANDES, RODRIGO TAVANELLI; et al. Genome-Based Characterization of Multidrug-Resistant Escherichia coli Isolated from Clinical Bovine Mastitis. Current Microbiology, v. 80, n. 3, p. 7-pg., . (15/19688-8)
GUERRA, SIMONY T.; ORSI, HENRIQUE; JOAQUIM, SAMEA F.; GUIMARAES, FELIPE F.; LOPES, BRUNA C.; DALANEZI, FELIPE M.; LEITE, DOMINGOS S.; LANGONI, HELIO; PANTOJA, JOSE C. F.; RALL, VERA L. M.; et al. Short communication: Investigation of extra-intestinal pathogenic Escherichia coli virulence genes, bacterial motility, and multidrug resistance pattern of strains isolated from dairy cows with different severity scores of clinicalmastitis. JOURNAL OF DAIRY SCIENCE, v. 103, n. 4, p. 3606-3614, . (15/19688-8, 17/08102-8)
DALANEZI, FELIPE M.; SCHMIDT, ELIZABETH M. S.; JOAQUIM, SAMEA F.; GUIMARAES, FELIPE F.; GUERRA, SIMONI T.; LOPES, BRUNA C.; CERRI, RONALDO L. A.; CHADWICK, CHRISTOPHER; LANGONI, HELIO. Concentrations of Acute-Phase Proteins in Milk from Cows with Clinical Mastitis Caused by Different Pathogens. PATHOGENS, v. 9, n. 9, . (15/26055-1, 15/19688-8)
BERTOLINI, AMANDA BEZERRA; THYSSEN, PATRICIA JACQUELINE; BRANDAO, PAULO EDUARDO; PRADO, ALINE MARRARA; SILVA, SHEILA OLIVEIRA DE SOUZA; MIONI, MATEUS DE SOUZA RIBEIRO; DE GOUVEA, FABIO LUCAS REZENDE; PANTOJA, JOSE CARLOS DE FIGUEIREDO; LANGONI, HELIO; GUIMARAES, FELIPE FREITAS; et al. Flies (Insecta, Diptera) collected in the environment of dairy farms as carriers of Rotavirus A and betacoronavirus. Journal of Applied Microbiology, v. N/A, p. 6-pg., . (15/19688-8)
JULIANO, L. C. B.; GOUVEA, F. L. R.; LATOSINSKI, G. S.; FABRI, F. H. H.; SALVADOR, T. B.; GUIMARAES, F. F.; RIBEIRO, M. G.; LANGONI, H.; RALL, V. L. M.; HERNANDES, R. T.; et al. Species diversity and antimicrobial resistance patterns of Enterococcus spp. isolated from mastitis cases, milking machine and the environment of dairy cows. Letters in Applied Microbiology, v. 75, n. 4, p. 9-pg., . (15/19688-8)
BERTOLINI, A. B.; PRADO, A. M.; THYSSEN, P. J.; DE SOUZA RIBEIRO MIONI, M.; DE GOUVEA, F. L. R.; DA SILVA LEITE, D.; LANGONI, H.; DE FIGUEIREDO PANTOJA, J. C.; RALL, V. M.; GUIMARAES, F. F.; et al. Prevalence of bovine mastitis-related pathogens, identified by mass spectrometry in flies (Insecta, Diptera) captured in the milking environment. Letters in Applied Microbiology, v. 75, n. 5, p. 14-pg., . (15/19688-8)

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