djuvant therapy with 1% alendronate gel for experimental periodontitis treatment in rat

Author(s):Show less -

Kajimoto, Natalia de Campos ^[1] ; Buischi, Yvonne de Paiva ^{[2, 1]} ; Loomer, Peter Michael ^[1] ; Bromage, Timothy G. ^[3] ; Ervolino, Edilson ^[4] ; Fucini, Stephen Enrico ; Pola, Natalia Marcumini ^[5] ; Pirovani, Beatriz Ommati ^[6] ; Sismeiro Morabito, Maria Juliana ^[6] ; de Almeida, Juliano Milanezi ^[6] ; Chaves Furlaneto, Flavia Aparecida ^[7] ; Hitomi Nagata, Maria Jose ^[6]

Affiliation

^[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Periodont, 7703 Floyd Curl Dr, San Antonio, TX 78229 - USA

^[2] NYU, Coll Dent, Dept Periodontol & Implant Dent, New York, NY - USA

^[3] NYU, Coll Dent, Dept Biomat & Biomimet, New York, NY - USA

^[4] Sao Paulo State Univ UNESP, Sch Dent, Dept Basic Sci, Div Histol, Aracatuba, SP - Brazil

^[5] Fed Univ Pelotas UFPEL, Sch Dent, Dept Semiol & Clin, Div Periodont, Pelotas, RS - Brazil

^[6] Sao Paulo State Univ UNESP, Sch Dent, Dept Surg & Integrated Clin, Div Periodontol, Aracatuba, SP - Brazil

^[7] Univ Sao Paulo, Sch Dent, Dept Oral Maxillofacial Surg & Periodontol, Div Periodontol, Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE; v. 51, n. 6, p. 374-385, DEC 2021.
• Web of Science Citations: 0

Abstract

Purpose: The aim of this study was to evaluate the effects of locally delivered 1% alendronate (ALN) gel used as an adjunct to non-invasive periodontal therapy. Methods: Ligature-induced periodontitis was performed in 96 rats. The ligature was tied in the cervical area of the mandibular left first molar. The animals were randomly divided into 4 groups: 1) NT, no treatment; 2) SRP, scaling and root planning; 3) SRP/PLA, SRP followed by filling the periodontal pocket with placebo gel (PLA); and 4) SRP/ALN, SRP followed by filling the periodontal pockets with 1% ALN gel. Histomorphometric (percentage of bone in the furcation region {[}PBF]) and immunohistochemical (receptor activator of nuclear factor -KB ligand, osteoprotegerin, and tartrate-resistant acid phosphatase) analyses were performed. Data were statistically analyzed, with the threshold of statistical significance set at P <= 0.05. Results: The SRP, SRP/PLA, and SRP/ALN groups presented a higher PBF than the NT group (P <= 0.01) at 7, 15, and 30 days. The SRP/ALN group presented a higher PBF than the SRP/PLA group in all experimental periods, as well as a higher PBF than the SRP group at 15 and 30 days. No differences were observed in the immunohistochemical analyses (P>0.05 for all). Conclusions: Locally delivered 1% ALN gel used as an adjunct to SRP enhanced bone regeneration in the furcation region in a rat model of experimental periodontitis. (AU)

• FAPESP's process: 18/03331-1 - Effects of alendronate gel used in periodontal therapy: a histomorphometric study
• Grantee: Maria Juliana Sismeiro Dias Morábito
• Support Opportunities: Scholarships in Brazil - Scientific Initiation