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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Dorsal Subiculum Is Not Necessary for Step-Through Inhibitory Avoidance Acquisition and Consolidation in Rats

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Author(s):
de Melo, Marcio Braga [1] ; Oliveira, Maria Gabriela Menezes [1] ; Favaro, Vanessa Manchim [1]
Total Authors: 3
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: BEHAVIORAL NEUROSCIENCE; v. 135, n. 6, p. 714-720, DEC 2021.
Web of Science Citations: 0
Abstract

The dorsal subiculum (DSub) has reciprocal connections with the dorsal hippocampus, and these regions play a role in spatial representation in contextual fear conditioning (CFC). Recently, we used AP5 and muscimol infusions to show that the DSub is required for CFC consolidation. The CFC component can be present in other learning tasks, such as step-through inhibitory avoidance (ST IA), which requires the dorsal hippocampus for acquisition and consolidation. This suggests that the DSub may be also involved in ST IA if the CFC component of the protocol is strong enough. Therefore, this study tested whether the DSub participates in ST IA acquisition and consolidation in male Wistar rats. Our data showed that pre-or posttraining infusions of AP5 or muscimol into the DSub did not affect ST IA acquisition and consolidation. We discuss the present results in relation to our previous findings, which showed the involvement of the DSub in CFC consolidation, and highlight some reasons that may explain the divergent results between the tasks. First, we note the possibility to escape from the unconditioned stimulus that occurs in ST IA, but not in CFC. We also suggest that the instrumental component of ST IA seems to be more prominent than the CFC one. Finally, we consider the possible influence of aspects of anxiety present in the ST IA, but not in CFC. These possible interpretations provide a broad framework in respect of the present results and raise new questions that demand further studies exploring the DSub function in inhibitory avoidance. (AU)

FAPESP's process: 17/09837-1 - Involvement of the glutamatergic and gabaergic systems in the dorsal subiculum on the processes of acquisition and memory consolidation in aversive learning tasks in rats
Grantee:Márcio Braga de Melo
Support Opportunities: Scholarships in Brazil - Master