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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prediction of Learned Resistance or Helplessness by Hippocampal-Prefrontal Cortical Network Activity during Stress

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Author(s):
Marques, Danilo Benette [1] ; Ruggiero, Rafael Naime [1] ; Bueno-Junior, Lezio Soares [1] ; Rossignoli, Matheus Teixeira [1] ; Leite, Joao Pereira [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF NEUROSCIENCE; v. 42, n. 1, p. 81-96, JAN 5 2022.
Web of Science Citations: 0
Abstract

The perception of control over a stressful experience may determine its impacts and generate resistance against future stressors. Although the medial prefrontal cortex (PFC) and the hippocampus (HPC) are implicated in the encoding of stressor controllability, the neural dynamics underlying this process are unknown. Here, we recorded HPC and PFC neural activities in male rats during the exposure to controllable, uncontrollable, or no shocks and investigated electrophysiological predictors of escape performance upon exposure to subsequent uncontrollable shocks. We were able to accurately discriminate stressed from nonstressed animals and predict resistant (R) or helpless (H) individuals based on hippocampal-cortical oscillatory dynamics. Remarkably, R animals exhibited an increase in theta power during CS, while H exhibited a decrease. Furthermore, R exhibited higher HPC to PFC theta synchronization during stress. Notably, HPC-PFC theta connectivity in the initial stress exposure showed strong correlations with escape performance evaluated days later. R rats also showed stronger theta coupling to both gamma oscillations and neuronal firing in the PFC. Finally, we found that these distinct features of network dynamics collectively formed a pattern that accurately predicted learned resistance and was lacking in H individuals. Our findings suggest that hippocampal-prefrontal network theta activity supports cognitive mechanisms of stress coping, whose impairment may underlie vulnerability to stress-related disorders. (AU)

FAPESP's process: 18/02303-4 - Study of the meso-cortico-limbic connectivity in animals submitted to early-life Status epilepticus and its relationship with psychiatric comorbidities
Grantee:Rafael Naime Ruggiero
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/17882-4 - Drug-resistant epilepsies: diagnostic challenges, associated comorbidities and new experimental approaches
Grantee:João Pereira Leite
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 11/04467-5 - Study of the effects of pretreatment with canabidiol and the induction of post-discharge on single hippocampal synaptic plasticity changes produced by ketamine via CA1-mPFC in anesthetized rats in vivo
Grantee:Matheus Teixeira Rossignoli
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 20/01510-6 - Study of the neural processing of meso-cortico-limbic circuitry during anhedonic-type behavior and its modulation by the endocannabinoid system
Grantee:Matheus Teixeira Rossignoli
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 12/06123-4 - Hippocampal-prefrontal synaptic plasticity in awake rats: effects of thalamic stimulation during natural sleep and implications for memory consolidation
Grantee:Lézio Soares Bueno Júnior
Support Opportunities: Scholarships in Brazil - Post-Doctoral