Study of the meso-cortico-limbic connectivity in animals submitted to early-life Status epilepticus and its relationship with psychiatric comorbidities

• Grant number: 18/02303-4
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2018
• End date: November 30, 2022
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: João Pereira Leite
• Grantee: Rafael Naime Ruggiero
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 16/17882-4 - Drug-resistant epilepsies: diagnostic challenges, associated comorbidities and new experimental approaches, AP.TEM

Abstract

Rats submitted to Status epilepticus (SE) during development present behavioral changes typical of animal models of psychosis, which correlate with changes in synaptic plasticity between the hippocampus and the prefrontal cortex (CPF). Our hypothesis is that SE affects the connectivity of meso-cortico-limbic circuits, which may underlie psychiatric comorbidities observed in epilepsy. Our aim is to investigate how the induction of SE during development affects the communication between the hippocampus, the prefrontal cortex and the ventral tegmental area during the performance of behavioral tests related to psychosis and depression. These findings will be related to cognitive impairments and markers of epileptogenesis, such as interictal activity and the presence of spontaneous seizures. For this purpose, we will use electrophysiology and optogenetic stimulation techniques, allowing a better understanding of the relationship between epiletogenesis and cognitive impairment, as well as the association of psychiatric comorbidities with temporal lobe epilepsy.

Scientific publications

(8)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

RUGGIERO, RAFAEL NAIME; MARQUES, DANILO BENETTE; ROSSIGNOLI, MATHEUS TEIXEIRA; DE ROSS, JANA BATISTA; PRIZON, TAMIRIS; BERALDO, IKARO JESUS SILVA; BUENO-JUNIOR, LEZIO SOARES; KANDRATAVICIUS, LUDMYLA; PEIXOTO-SANTOS, JOSE EDUARDO; LOPES-AGUIAR, CLEITON; et al. Dysfunctional hippocampal-prefrontal network underlies a multidimensional neuropsychiatric phenotype following early-life seizure. eLIFE, v. 12, p. 31-pg., 2024-04-09. (22/16812-3, 16/17882-4, 18/02303-4, 20/01510-6)

MARQUES, DANILO BENETTE; RUGGIERO, RAFAEL NAIME; BUENO-JUNIOR, LEZIO SOARES; ROSSIGNOLI, MATHEUS TEIXEIRA; LEITE, JOAO PEREIRA. Prediction of Learned Resistance or Helplessness by Hippocampal-Prefrontal Cortical Network Activity during Stress. JOURNAL OF NEUROSCIENCE, v. 42, n. 1, p. 81-96, JAN 5 2022. (18/02303-4, 16/17882-4, 11/04467-5, 20/01510-6, 12/06123-4)

LOPES-AGUIAR, CLEITON; RUGGIERO, RAFAEL N.; ROSSIGNOLI, MATHEUS T.; ESTEVES, INGRID DE MIRANDA; PEIXOTO-SANTOS, JOSE EDUARDO; ROMCY-PEREIRA, RODRIGO N.; LEITE, JOAO P.. Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo. SCIENTIFIC REPORTS, v. 10, n. 1, APR 28 2020. (16/17882-4, 18/02303-4, 14/18211-0)

MENDES, RENAN AUGUSTO VIANA; ZACHARIAS, LEONARDO RAKAUSKAS; RUGGIERO, RAFAEL NAIME; LEITE, JOAO PEREIRA; MORAES, MARCIO FLAVIO DUTRA; LOPES-AGUIAR, CLEITON. Hijacking of hippocampal-cortical oscillatory coupling during sleep in temporal lobe epilepsy. Epilepsy & Behavior, v. 121, n. B, AUG 2021. (18/02303-4, 16/17882-4)

DE OLIVEIRA-JUNIOR, BENEDITO ALVES; MARQUES, DANILO BENETTE; ROSSIGNOLI, MATHEUS TEIXEIRA; PRIZON, TAMIRIS; LEITE, JOAO PEREIRA; RUGGIERO, RAFAEL NAIME. Multidimensional behavioral profiles associated with resilience and susceptibility after inescapable stress. SCIENTIFIC REPORTS, v. 14, n. 1, p. 18-pg., 2024-04-27. (22/16812-3, 16/17882-4, 18/02303-4, 20/01510-6)

RUGGIERO, RAFAEL NAIME; PEIXOTO-SANTOS, JOSE EDUARDO; BUENO-JUNIOR, LEZIO SOARES; VALENTE, KETTE D.; LEITE, JOAO PEREIRA. Editorial: Psychiatric Comorbidities in the Epilepsies: Extensive Mechanisms and Broad Questions. FRONTIERS IN INTEGRATIVE NEUROSCIENCE, v. 16, p. 4-pg., 2022-06-17. (16/17882-4, 18/02303-4)

LOPES-AGUIAR, CLEITON; RUGGIERO, RAFAEL N.; ROSSIGNOLI, MATHEUS T.; ESTEVES, INGRID DE MIRANDA; PEIXOTO-SANTOS, JOSE EDUARDO; ROMCY-PEREIRA, RODRIGO N.; LEITE, JOAO P.. Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo. SCIENTIFIC REPORTS, v. 10, n. 1, p. 15-pg., 2020-04-28. (16/17882-4, 18/02303-4, 14/18211-0)

RUGGIERO, RAFAEL NAIME; ROSSIGNOLI, MATHEUS TEIXEIRA; MARQUES, DANILO BENETTE; DE SOUSA, BRUNO MONTEIRO; ROMCY-PEREIRA, RODRIGO NEVES; LOPES-AGUIAR, CLEITON; LEITE, JOAO PEREIRA. Neuromodulation of Hippocampal-Prefrontal Cortical Synaptic Plasticity and Functional Connectivity: Implications for Neuropsychiatric Disorders. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 15, OCT 11 2021. (20/01510-6, 16/17882-4, 18/02303-4)