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Study of the meso-cortico-limbic connectivity in animals submitted to early-life Status epilepticus and its relationship with psychiatric comorbidities

Grant number: 18/02303-4
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): March 01, 2018
Effective date (End): November 30, 2022
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:João Pereira Leite
Grantee:Rafael Naime Ruggiero
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:16/17882-4 - Drug-resistant epilepsies: diagnostic challenges, associated comorbidities and new experimental approaches, AP.TEM


Rats submitted to Status epilepticus (SE) during development present behavioral changes typical of animal models of psychosis, which correlate with changes in synaptic plasticity between the hippocampus and the prefrontal cortex (CPF). Our hypothesis is that SE affects the connectivity of meso-cortico-limbic circuits, which may underlie psychiatric comorbidities observed in epilepsy. Our aim is to investigate how the induction of SE during development affects the communication between the hippocampus, the prefrontal cortex and the ventral tegmental area during the performance of behavioral tests related to psychosis and depression. These findings will be related to cognitive impairments and markers of epileptogenesis, such as interictal activity and the presence of spontaneous seizures. For this purpose, we will use electrophysiology and optogenetic stimulation techniques, allowing a better understanding of the relationship between epiletogenesis and cognitive impairment, as well as the association of psychiatric comorbidities with temporal lobe epilepsy.

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOPES-AGUIAR, CLEITON; RUGGIERO, RAFAEL N.; ROSSIGNOLI, MATHEUS T.; ESTEVES, INGRID DE MIRANDA; PEIXOTO-SANTOS, JOSE EDUARDO; ROMCY-PEREIRA, RODRIGO N.; LEITE, JOAO P.. Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo. SCIENTIFIC REPORTS, v. 10, n. 1, . (16/17882-4, 18/02303-4, 14/18211-0)
MENDES, RENAN AUGUSTO VIANA; ZACHARIAS, LEONARDO RAKAUSKAS; RUGGIERO, RAFAEL NAIME; LEITE, JOAO PEREIRA; MORAES, MARCIO FLAVIO DUTRA; LOPES-AGUIAR, CLEITON. Hijacking of hippocampal-cortical oscillatory coupling during sleep in temporal lobe epilepsy. Epilepsy & Behavior, v. 121, n. B, . (18/02303-4, 16/17882-4)
MARQUES, DANILO BENETTE; RUGGIERO, RAFAEL NAIME; BUENO-JUNIOR, LEZIO SOARES; ROSSIGNOLI, MATHEUS TEIXEIRA; LEITE, JOAO PEREIRA. Prediction of Learned Resistance or Helplessness by Hippocampal-Prefrontal Cortical Network Activity during Stress. JOURNAL OF NEUROSCIENCE, v. 42, n. 1, p. 81-96, . (18/02303-4, 16/17882-4, 11/04467-5, 20/01510-6, 12/06123-4)
RUGGIERO, RAFAEL NAIME; PEIXOTO-SANTOS, JOSE EDUARDO; BUENO-JUNIOR, LEZIO SOARES; VALENTE, KETTE D.; LEITE, JOAO PEREIRA. Editorial: Psychiatric Comorbidities in the Epilepsies: Extensive Mechanisms and Broad Questions. FRONTIERS IN INTEGRATIVE NEUROSCIENCE, v. 16, p. 4-pg., . (16/17882-4, 18/02303-4)
RUGGIERO, RAFAEL NAIME; ROSSIGNOLI, MATHEUS TEIXEIRA; MARQUES, DANILO BENETTE; DE SOUSA, BRUNO MONTEIRO; ROMCY-PEREIRA, RODRIGO NEVES; LOPES-AGUIAR, CLEITON; LEITE, JOAO PEREIRA. Neuromodulation of Hippocampal-Prefrontal Cortical Synaptic Plasticity and Functional Connectivity: Implications for Neuropsychiatric Disorders. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 15, . (20/01510-6, 16/17882-4, 18/02303-4)

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