TRANSCRIPTOME ANALYSIS IN ANIMAL MODELS OF MESIAL TEMPORAL LOBE EPILEPSY

• Grant number: 13/08635-5
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): May 01, 2014
• Effective date (End): April 30, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Iscia Teresinha Lopes Cendes
• Grantee: Alexandre Hilário Berenguer de Matos
• Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 11/50680-2 - Multimodal investigation of epileptogenesis with emphasis in the implementation of new animal models and new tools, AP.TEM

Abstract

Epilepsy affects approximately 1% of the world population and mesial temporal lobe epilepsy (TLE) is the most frequent type, representing 40% of the patients, these are often refractory to medical treatment. One of the most used tools to study the mechanisms involved in TLE are animal models. Despite several animal models currently available and widely studied, the majority of these present lesions which are not commonly identified in patients such as: ischemia, trauma and status epilepticus (SE). Therefore, we propose to work with animal models which have been more recently described and that present lesions which are closer to that found in patients with TLE. We will study gene expression using next generation sequencing tecnology in two animal models of TLE. In addition, we will make these data available in public databases.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CANTO, AMANDA M.; MATOS, ALEXANDRE H. B.; GODOI, ALEXANDRE B.; VIEIRA, ANDRE S.; AOYAMA, BEATRIZ B.; ROCHA, CRISTIANE S.; HENNING, BARBARA; CARVALHO, BENILTON S.; PASCOAL, VINICIUS D. B.; VEIGA, DIOGO F. T.; GILIOLI, ROVILSON; CENDES, FERNANDO; LOPES-CENDES, ISCIA. Multi-omics analysis suggests enhanced epileptogenesis in theCornu Ammonis3 of the pilocarpine model of mesial temporal lobe epilepsy. HIPPOCAMPUS, v. 31, n. 2, p. 122-139, FEB 2021. Web of Science Citations: 1.

CANTO, AMANDA M.; VIEIRA, ANDRE S.; MATOS, ALEXANDRE H. B.; CARVALHO, BENILTON S.; HENNING, BARBARA; NORWOOD, BRAXTON A.; BAUER, SEBASTIAN; ROSENOW, FELIX; GILIOLI, ROVILSON; CENDES, FERNANDO; LOPES-CENDES, ISCIA. Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances. SCIENTIFIC REPORTS, v. 10, n. 1 MAR 10 2020. Web of Science Citations: 0.