Synthesis of novel poly(methacrylic acid)/beta-cyclodextrin dual grafted MWCNT-based nanocomposite and its use as electrochemical sensing platform for highly selective determination of cocaine

Author(s)

Capelari, Tainara Boareto ^[1] ; Mendonca, Jhessica de Cassia ^[1] ; da Rocha, Luana Rianne ^[1] ; Prete, Maiyara Carolyne ^[1] ; Angelis, Pedro Nunes ^[1] ; Camargo, Luan Pereira ^[1] ; Dall'Antonia, Luiz Henrique ^{[2, 1]} ; Teixeira Tarley, Cesar Ricardo ^{[2, 1]}

Affiliation

^[1] Univ Estadual Londrina UEL, Ctr Ciencias Exatas, Dept Quim, Rodovia Celso Garcia Cid, PR 445 Km 380, BR-86050482 Londrina, Parana - Brazil

^[2] Univ Estadual Campinas UNICAMP, Dept Quim Analit, Inst Nacl Ciencia & Tecnol INCT Bioanalit, Inst Quim, Cidade Univ Zeferino Vaz S-N, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 880, JAN 1 2021.
• Web of Science Citations: 1

Abstract

The assessment of a novel electrochemical sensing platform based on poly(methacrylic acid) (poly(MAA)) and beta cyclodextrin (beta-CD) grafted onto multi-walled carbon nanotubes (MWCNT) for highly sensitive and selective cocaine (COC) determination in seized samples is reported. Nanocomposite characterization was performed by FT-IR, Raman Spectroscopy, X-ray diffraction, TGA, SEM, TEM, nitrogen adsorption/desorption and static contact angle. The poly (MAA)/MWCNT/beta-CD at 3.0 mg mL(-1) concentration in DMF containing 0.7% of Nafion (R) was cast on the surface of glassy carbon electrode (GCE) by the drop-castingmethod. The nanocomposite modified electrode showed substantial improvement in terms of selectivity and sensitivity in the COC determination as a result of the synergic effect of MWCNT, poly(MAA), and beta-CD. By using differential pulse voltammetry (DPV) under optimized conditions (scan rate of 28.0 mV s(-1), pulse amplitude of 164.0 mV and modulation time of 7.0 ms) and at pH 7.0 in 0.1 mol L-1 Britton-Robinson (BR) buffer, a linear response range from 12.2 to 200.0 mu mol L-1 with a limit of detection (LOD) of 3.6 mu mol L-1 was obtained. The modified electrode showed outstanding selectivity towards COC determination even in the presence of adulterants usually found in seized COC sample, including caffeine, lidocaine, phenacetin, benzocaine, paracetamol, procaine, and levamisole. The proposed method was applied to COC determination in street seized sample and the accuracy was attested by HPLD-DAD. (AU)

• FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
• Grantee: Marco Aurelio Zezzi Arruda
• Support Opportunities: Research Projects - Thematic Grants