Development and application of new nanoestructurated chemical sensors based on biomimetic polymers

• Grant number: 14/25264-3
• Support Opportunities: Regular Research Grants
• Duration: July 01, 2015 - June 30, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Maria Del Pilar Taboada Sotomayor
• Grantee: Maria Del Pilar Taboada Sotomayor
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

This research project aims to develop new nanostructured chemical sensors based on polymers with molecular imprinting (MIP, molecularly imprinted polymers) using alternative systems transducers unexplored and scarce in the literature. For this, biomimetic polymers (MIP) will be immobilized on the surface of glass optical fibers or magnetic nanoparticles, to obtain the corresponding sensing phases, which will be properly optimized, as well also optimized the conditions of sensors analysis for detecting sensitive and selectively the pesticides, ametryne and metribuzin (classic pollutants) and sulfamide antibiotic and the dyes, acid violet 19 and basic green 1, considered as emerging pollutants. Subsequently it could be applied in biological, environmental and food samples according to the case. The choice of analytes was based on its environmental importance and their relevant use which is exist in the literature in relation to its monitoring through chemical sensors based on MIP and the main possibility of monitoring them through of systems different to the electrochemical, taking a step forward in the development of sensors not only in Brazil, but also for the world. In the case of dyes and antibiotic will be used the optical transduction, since the concentration of these analytes to the sensor surface may be monitored by the change in absorbance or reflectance due to the color generated in the sensing phase coming from these analytes. Pesticides will be monitored using the new sensing platforms based on the magnetic-MIP, mainly because it has been shown in the literature and in our research group, than the magnetic nanoparticles modified by MIP exhibit high affinity for its analyte which will enable the extraction and previous pre-concentration of the pesticides, which commonly found in complex matrices and at low concentrations and could be taken by a magnetic-electrode to perform the measurements in a cleaner solution. So this project aims to show the real potential of these highly selective nanoporous polymers (biomimetic polymers) as new and alternatives sensing platforms to existing ones, which are coupled to the appropriate transduction systems having the additional advantage of being more durable and stable than the conventional biosensors and opening the possibility of direct analysis in the different biological matrices such as industrial waste water, river water or non-aqueous medium, extending the application of biosensors (highly selective, but unstable under adverse and extreme conditions) for the use of MIP as biomimetic recognizers. (AU)

Scientific publications

(12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FRANCO, JEFFERSON HONORIO; BEN AISSA, ALEJANDRA; BESSEGATO, GUILHERME GARCIA; MARTINEZ FAJARDO, LAURA; BOLDRIN ZANONI, MARIA VALNICE; ISABEL PIVIDORI, MARIA; TABOADA SOTOMAYOR, MARIA DEL PILAR. Assessment of molecularly imprinted polymers (MIPs) in the preconcentration of disperse red 73 dye prior to photoelectrocatalytic treatment. Environmental Science and Pollution Research, v. 24, n. 4, p. 4134-4143, FEB 2017. (14/03679-7, 14/25264-3)

WONG, ADEMAR; SCONTRI, MATEUS; MATERON, ELSA MARIA; LANZA, MARCOS R. V.; SOTOMAYOR, MARIA D. P. T.. Development and application of an electrochemical sensor modified with multi-walled carbon nanotubes and graphene oxide for the sensitive and selective detection of tetracycline. Journal of Electroanalytical Chemistry, v. 757, p. 250-257, NOV 15 2015. (14/25264-3)

WONG, ADEMAR; FOGUEL, MARCOS VINICIUS; KHAN, SABIR; DE OLIVEIRA, FERNANDA MIDORI; TEIXEIRA TARLEY, CESAR RICARDO; SOTOMAYOR, MARIA D. P. T.. DEVELOPMENT OF AN ELECTROCHEMICAL SENSOR MODIFIED WITH MWCNT-COOH AND MIP FOR DETECTION OF DIURON. Electrochimica Acta, v. 182, p. 122-130, NOV 10 2015. (11/03008-7, 14/25264-3)

MORTARI, BIANCA; KHAN, SABIR; WONG, ADEMAR; FIREMAN DUTRA, ROSA AMALIA; TABOADA SOTOMAYOR, MARIA DEL PILAR. Next generation of optodes coupling plastic antibody with optical fibers for selective quantification of Acid Green 16. SENSORS AND ACTUATORS B-CHEMICAL, v. 305, FEB 15 2020. (14/50945-4, 14/25264-3)

RUIZ-CORDOVA, GERSON A.; KHAN, SABIR; GONCALVES, LUIS MOREIRA; PIVIDORI, MARIA ISABEL; PICASSO, GINO; SOTOMAYOR, MARIA DEL PILAR T.. Electrochemical sensing using magnetic molecularly imprinted polymer particles previously captured by a magneto-sensor. Talanta, v. 181, p. 19-23, MAY 1 2018. (14/50945-4, 16/06926-0, 14/25264-3)

QUINTO, MIGUEL LUNA; KHAN, SABIR; PICASSO, GINO; TABOADA SOTOMAYOR, MARIA DEL PILAR. Synthesis, characterization, and evaluation of a selective molecularly imprinted polymer for quantification of the textile dye acid violet 19 in real water samples. JOURNAL OF HAZARDOUS MATERIALS, v. 384, FEB 15 2020. (14/50945-4, 14/25264-3)

ADAUTO, ANAIS; KHAN, SABIR; DA SILVA, MATHEUS AUGUSTO; GOMES NETO, JOSE ANCHIETA; PICASSO, GINO; TABOADA SOTOMAYOR, MARIA DEL PILAR. Synthesis, characterization and application of a novel ion hybrid imprinted polymer to adsorb Cd(II) in different samples. Environmental Research, v. 187, AUG 2020. (14/50945-4, 14/25264-3)

LIMA MOURA, SILIO; MARTINEZ FAJARDO, LAURA; CUNHA, LEONARDO DOS ANJOS; TABOADA SOTOMAYOR, MARIA DEL PILAR; CORRETO MACHADO, FRANCISCO BOLIVAR; ARAUJO FERRAO, LUIZ FERNANDO; ISABEL PIVIDORI, MARIA. Theoretical and experimental study for the biomimetic recognition of levothyroxine hormone on magnetic molecularly imprinted polymer. BIOSENSORS & BIOELECTRONICS, v. 107, p. 203-210, JUN 1 2018. (14/50945-4, 14/25264-3, 17/07707-3)

SILVA, LUCAS M.; FOGUEL, V, MARCOS; SOTOMAYOR, MARIA DEL PILAR T.. Use of two functional monomers for a new approach to the synthesis of a magnetic molecularly imprinted polymer for ciprofloxacin. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, v. 15, p. 511-523, NOV-DEC 2021. (14/25264-3, 19/00677-7)

KHAN, SABIR; HUSSAIN, SAJJAD; WONG, ADEMAR; FOGUEL, MARCOS VINICIUS; GONCALVES, LUIS MOREIRA; PIVIDORI GURGO, MARIA ISABEL; TABOADA SOTOMAYOR, MARIA DEL PILAR. Synthesis and characterization of magnetic-molecularly imprinted polymers for the HPLC-UV analysis of ametryn. REACTIVE & FUNCTIONAL POLYMERS, v. 122, p. 175-182, JAN 2018. (16/06926-0, 14/25264-3)

PEDROSO, MARIELE MUCIO; FOGUEL, MARCOS VINICIUS; SIQUEIRA SILVA, DULCE HELENA; TABOADA SOTOMAYOR, MARIA DEL PILAR; YAMANAKA, HIDEKO. Electrochemical sensor for dodecyl gallate determination based on electropolymerized molecularly imprinted polymer. SENSORS AND ACTUATORS B-CHEMICAL, v. 253, p. 180-186, DEC 2017. (14/25264-3, 13/07600-3, 13/05448-0)

FOGUEL, MARCOS VINICIUS; BELLO PEDRO, NATACHA THAISA; WONG, ADEMAR; KHAN, SABIR; BOLDRIN ZANONI, MARIA VALNICE; TABOADA SOTOMAYOR, MARIA DEL PILAR. Synthesis and evaluation of a molecularly imprinted polymer for selective adsorption and quantification of Acid Green 16 textile dye in water samples. Talanta, v. 170, p. 244-251, AUG 1 2017. (14/07009-6, 08/10449-7, 11/17552-0, 14/25264-3)