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RADes-MIP - preparation and synthesis of materials for development of rapid analysis devices for monitoring emerging pollutants using highly selective biomimetic polymers based on molecular printing technology


The definition of emergent pollutant arose in the 1980s and refers to those compounds that were previously "unknown or unrecognized" as contaminants. These residues of drugs, cosmetics, dyes, pesticides and other "polluting" substances are being found in wastewater, rivers and surface waters. Being launched into the environment indiscriminately and still without any regulation by the legislative and government agencies. Many of them pollute the aquatic biota, and consequently, its entire food chain, including humans, producing damage yet unknown. Due to the drawbacks that can be caused by these compounds, materials and methods for detecting and quantifying them quickly have attracted great interest, especially in recent years, given the warning raised by the lack of knowledge regarding the toxicity of emerging pollutants. In this context, molecularly imprinted polymers (MIP) are materials applied in the identification and preconcentration of different types of molecules with high selectivity. MIPs are materials that have been applied in different areas of knowledge and coupled with various analytical techniques. Among them, the most current being the replacement of biological materials, in biomimetic immunoassays and immunosensors. Among these biomimetic systems that can be explored, in an unprecedented way, and using MIP as actuators, are the Lateral Flow (FL) devices and in slides to TLC separation (thin layer chromatography), in search of fast results, high selectivity and stability, low cost and easy handling. On the other hand, the literature has recently shown the use of MIPs as recognition phase in electrochemical sensors, and can still be explored in optical transduction systems (optodes). On these bases, the present project proposes the optimized synthesis of different novel materials in the core@shell format (nanoparticle@MIP) to be used, in a next project, as recognition phase (replacing antibodies) in the development of the rapid analysis devices based on FL, TLC and sensors, aim at the use of the materials synthesized in this first time. To this propose, will be synthesized initially hybrid materials of silicap@MIP-tetracycline (SiO2p@MIP-TET); silica@MIP-atrazine (SiO2@MIP-ATRAZ) and quantum-dots@estradiol (QD@MIP-EST) All materials to be synthesized are of immediate interest to the research group, since the students involved in the project must prepare monographs, dissertations and theses related to them. Additionally, in this project the initial assembly and viability of RADES-MIP systems should also be performed as follows: SiO2p@MIP-TET will be used in the construction of the FL devices, the SiO2@MIP-ATRAZ, will be used in the construction of TLC plates; and QD@MIP-EST will be used in the construction of optical sensors. Emphasizing that the detailed development of the RADES-MIPs as analytical tools should be carried out in a next project. Finally, the technological potential and innovation of this project, as well as the opportunity to train high-quality human resources, covering areas of knowledge, from the synthesis of nanomaterials to the application of new analytical methods, justifies the investment and the granting of this proposal. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, ANDERSON M.; WONG, ADEMAR; PRADO, THIAGO M.; FAVA, ELSON L.; FATIBELLO-FILHO, ORLANDO; SOTOMAYOR, MARIA D. P. T.; MORAES, FERNANDO C. Voltammetric determination of ethinylestradiol using screen-printed electrode modified with functionalized graphene, graphene quantum dots and magnetic nanoparticles coated with molecularly imprinted polymers. Talanta, v. 224, MAR 1 2021. Web of Science Citations: 0.
WONG, ADEMAR; SANTOS, ANDERSON MARTIN; ALVES, RAFAEL DA FONSECA; VICENTINI, FERNANDO CAMPANHA; FATIBELLO-FILHO, ORLANDO; TABOADA SOTOMAYOR, MARIA DEL PILAR. Simultaneous determination of direct yellow 50, tryptophan, carbendazim, and caffeine in environmental and biological fluid samples using graphite pencil electrode modified with palladium nanoparticles. Talanta, v. 222, JAN 15 2021. Web of Science Citations: 2.
MESA, RUDDY L.; VILLA, JAVIER E. L.; KHAN, SABIR; ALVES PEIXOTO, RAFAELLA R.; MORGANO, MARCELO A.; GONCALVES, LUIS MOREIRA; SOTOMAYOR, MARIA D. P. T.; PICASSO, GINO. Rational Design of an Ion-Imprinted Polymer for Aqueous Methylmercury Sorption. NANOMATERIALS, v. 10, n. 12 DEC 2020. Web of Science Citations: 0.

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