RADes-MIP - preparation and synthesis of materials for development of rapid analysis devices for monitoring emerging pollutants using highly selective biomimetic polymers based on molecular printing technology

• Grant number: 19/00677-7
• Support Opportunities: Regular Research Grants
• Duration: December 01, 2019 - November 30, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Maria Del Pilar Taboada Sotomayor
• Grantee: Maria Del Pilar Taboada Sotomayor
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The definition of emergent pollutant arose in the 1980s and refers to those compounds that were previously "unknown or unrecognized" as contaminants. These residues of drugs, cosmetics, dyes, pesticides and other "polluting" substances are being found in wastewater, rivers and surface waters. Being launched into the environment indiscriminately and still without any regulation by the legislative and government agencies. Many of them pollute the aquatic biota, and consequently, its entire food chain, including humans, producing damage yet unknown. Due to the drawbacks that can be caused by these compounds, materials and methods for detecting and quantifying them quickly have attracted great interest, especially in recent years, given the warning raised by the lack of knowledge regarding the toxicity of emerging pollutants. In this context, molecularly imprinted polymers (MIP) are materials applied in the identification and preconcentration of different types of molecules with high selectivity. MIPs are materials that have been applied in different areas of knowledge and coupled with various analytical techniques. Among them, the most current being the replacement of biological materials, in biomimetic immunoassays and immunosensors. Among these biomimetic systems that can be explored, in an unprecedented way, and using MIP as actuators, are the Lateral Flow (FL) devices and in slides to TLC separation (thin layer chromatography), in search of fast results, high selectivity and stability, low cost and easy handling. On the other hand, the literature has recently shown the use of MIPs as recognition phase in electrochemical sensors, and can still be explored in optical transduction systems (optodes). On these bases, the present project proposes the optimized synthesis of different novel materials in the core@shell format (nanoparticle@MIP) to be used, in a next project, as recognition phase (replacing antibodies) in the development of the rapid analysis devices based on FL, TLC and sensors, aim at the use of the materials synthesized in this first time. To this propose, will be synthesized initially hybrid materials of silicap@MIP-tetracycline (SiO2p@MIP-TET); silica@MIP-atrazine (SiO2@MIP-ATRAZ) and quantum-dots@estradiol (QD@MIP-EST) All materials to be synthesized are of immediate interest to the research group, since the students involved in the project must prepare monographs, dissertations and theses related to them. Additionally, in this project the initial assembly and viability of RADES-MIP systems should also be performed as follows: SiO2p@MIP-TET will be used in the construction of the FL devices, the SiO2@MIP-ATRAZ, will be used in the construction of TLC plates; and QD@MIP-EST will be used in the construction of optical sensors. Emphasizing that the detailed development of the RADES-MIPs as analytical tools should be carried out in a next project. Finally, the technological potential and innovation of this project, as well as the opportunity to train high-quality human resources, covering areas of knowledge, from the synthesis of nanomaterials to the application of new analytical methods, justifies the investment and the granting of this proposal. (AU)

Scientific publications

(21)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VILLA, JAVIER E. L.; KHAN, SABIR; NERES, LUCAS C. S.; SOTOMAYOR, MARIA D. P. T.. Preparation of a magnetic molecularly imprinted polymer for non-invasive determination of cortisol. JOURNAL OF POLYMER RESEARCH, v. 28, n. 8, AUG 2021. (19/00677-7, 14/50945-4, 17/24196-2)

SANTOS, ANDERSON M.; WONG, ADEMAR; PRADO, THIAGO M.; FAVA, ELSON L.; FATIBELLO-FILHO, ORLANDO; SOTOMAYOR, MARIA D. P. T.; MORAES, FERNANDO C.. Voltammetric determination of ethinylestradiol using screen-printed electrode modified with functionalized graphene, graphene quantum dots and magnetic nanoparticles coated with molecularly imprinted polymers. Talanta, v. 224, MAR 1 2021. (16/10012-4, 20/01050-5, 17/10118-0, 19/00677-7)

MORTARI, BIANCA; KHAN, SABIR; WONG, ADEMAR; SOTOMAYOR, MARIA D. P. T.. A spot test for direct quantification of acid green 16 adsorbed on a molecularly imprinted polymer through diffuse reflectance measurements. ANALYTICAL METHODS, v. 13, n. 4, p. 453-461, JAN 28 2021. (19/00677-7, 14/50945-4)

WONG, ADEMAR; SANTOS, ANDERSON MARTIN; ALVES, RAFAEL DA FONSECA; VICENTINI, FERNANDO CAMPANHA; FATIBELLO-FILHO, ORLANDO; TABOADA SOTOMAYOR, MARIA DEL PILAR. Simultaneous determination of direct yellow 50, tryptophan, carbendazim, and caffeine in environmental and biological fluid samples using graphite pencil electrode modified with palladium nanoparticles. Talanta, v. 222, JAN 15 2021. (14/50945-4, 19/00677-7, 20/01050-5)

GARCIA, SARA MANENTE; WONG, ADEMAR; KHAN, SABIR; SOTOMAYOR, MARIA D. P. T.. A simple, sensitive and efficient electrochemical platform based on carbon paste electrode modified with Fe3O4@MIP and graphene oxide for folic acid determination in different matrices. Talanta, v. 229, JUL 1 2021. (18/09432-4, 19/00677-7)

WONG, ADEMAR; RIOJAS, ANDY CARDENAS; BAENA-MONCADA, ANGELICA M.; SOTOMAYOR, MARIA D. P. T.. A new electrochemical platform based on carbon black paste electrode modified with ?-cyclodextrin and hierarchical porous carbon used for the simultaneous determination of dipyrone and codeine. Microchemical Journal, v. 164, MAY 2021. (14/50945-4, 19/00677-7)

WONG, ADEMAR; DE LIMA, DOUGLAS GONCALVES; FERREIRA, PRISCILA ALVES; KHAN, SABIR; BEZERRA DA SILVA, RODRIGO AMORIM; BRITO DE FARIA, JORGE LUIS; TABOADA SOTOMAYOR, MARIA DEL PILAR. Voltammetric sensing of glyphosate in different samples using carbon paste electrode modified with biochar and copper(II) hexadecafluoro-29H,31 phtalocyanine complex. Journal of Applied Electrochemistry, v. 51, n. 5, p. 761-768, MAY 2021. (19/00677-7)

KHAN, SABIR; WONG, ADEMAR; RYCHLIK, MICHAEL; SOTOMAYOR, MARIA DEL PILAR TABOADA. A Novel Synthesis of a Magnetic Porous Imprinted Polymer by Polyol Method Coupled with Electrochemical Biomimetic Sensor for the Detection of Folate in Food Samples. CHEMOSENSORS, v. 10, n. 11, p. 16-pg., 2022-11-01. (14/50945-4, 19/00677-7)

MALIK, SUMEET; KHAN, ADNAN; RAHMAN, GUL; ALI, NAUMAN; KHAN, HAMAYUN; KHAN, SABIR; SOTOMAYOR, MARIA D. P. T.. Core-shell magnetic molecularly imprinted polymer for selective recognition and detection of sunset yellow in aqueous environment and real samples. Environmental Research, v. 212, p. 10-pg., 2022-04-02. (19/00677-7)

RUIZ-CORDOVA, GERSON A.; VILLA, JAVIER E. L.; KHAN, SABIR; PICASSO, GINO; SOTOMAYOR, MARIA DEL PILAR TABOADA. urface molecularly imprinted core-shell nanoparticles and reflectance spectroscopy for direct determination of tartrazine in soft drink. Analytica Chimica Acta, v. 1159, MAY 15 2021. (17/24196-2, 19/00677-7, 14/50945-4)

SILVA, LUCAS M.; FOGUEL, V, MARCOS; SOTOMAYOR, MARIA DEL PILAR T.. Use of two functional monomers for a new approach to the synthesis of a magnetic molecularly imprinted polymer for ciprofloxacin. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, v. 15, p. 511-523, NOV-DEC 2021. (14/25264-3, 19/00677-7)

SILVA NERES, LUCAS CHAGAS; FELICIANO, GUSTAVO TROIANO; DUTRA, ROSA FIREMAN; TABOADA SOTOMAYOR, MARIA DEL PILAR. Development of a selective molecularly imprinted polymer for troponin T detection: a theoretical-experimental approach. MATERIALS TODAY COMMUNICATIONS, v. 30, MAR 2022. (19/00677-7, 14/50945-4)

MESA, RUDDY L.; VILLA, JAVIER E. L.; KHAN, SABIR; ALVES PEIXOTO, RAFAELLA R.; MORGANO, MARCELO A.; GONCALVES, LUIS MOREIRA; SOTOMAYOR, MARIA D. P. T.; PICASSO, GINO. Rational Design of an Ion-Imprinted Polymer for Aqueous Methylmercury Sorption. NANOMATERIALS, v. 10, n. 12, DEC 2020. (19/00677-7, 14/50945-4, 18/14425-7)

MEZA LOPEZ, FLOR DE LISS; KHAN, SABIR; DA SILVA, MATHEUS AUGUSTO; GOMES NETO, JOSE ANCHIETA; PICASSO, GINO; TABOADA SOTOMAYOR, MARIA DEL PILAR. Systematic study on the synthesis of novel ion-imprinted polymers based on rhodizonate for the highly selective removal of Pb(II). REACTIVE & FUNCTIONAL POLYMERS, v. 159, FEB 2021. (14/50945-4, 19/00677-7)

QUINTO, MIGUEL LUNA; KHAN, SABIR; VEGA-CHACON, JAIME; MORTARI, BIANCA; WONG, ADEMAR; SOTOMAYOR, MARIA DEL PILAR TABOADA; PICASSO, GINO. Development and Characterization of a Molecularly Imprinted Polymer for the Selective Removal of Brilliant Green Textile Dye from River and Textile Industry Effluents. POLYMERS, v. 15, n. 18, p. 14-pg., 2023-09-01. (19/00677-7, 14/50945-4, 18/14425-7)

RUIZ-CORDOVA, GERSON A.; VILLA, JAVIER E. L.; KHAN, SABIR; PICASSO, GINO; SOTOMAYOR, MARIA DEL PILAR TABOADA. Surface molecularly imprinted core-shell nanoparticles and reflectance spectroscopy for direct determination of tartrazine in soft drinks. Analytica Chimica Acta, v. 1159, p. 8-pg., 2021-03-30. (17/24196-2, 19/00677-7, 14/50945-4)

WONG, ADEMAR; M. SANTOS, ANDERSON; A. SILVA, TIAGO; MORAES, FERNANDO C.; FATIBELLO-FILHO, ORLANDO; SOTOMAYOR, MARIA D. P. T.. Sensitive and Selective Voltammetric Determination of Ciprofloxacin Using Screen-printed Electrodes Modified with Carbon Black and Magnetic-molecularly Imprinted Polymer. Electroanalysis, v. N/A, p. 11-pg., 2022-05-31. (20/01050-5, 17/10118-0, 14/50945-4, 19/00677-7)

ZEB, SHAKEEL; WONG, ADEMAR; KHAN, SABIR; HUSSAIN, SAJJAD; SOTOMAYOR, MARIA D. P. T.. Using magnetic nanoparticles/MIP-based electrochemical sensor for quantification of tetracycline in milk samples. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 900, NOV 1 2021. (19/00677-7, 14/50945-4)

ADAUTO, ANAIS; WONG, ADEMAR; KHAN, SABIR; PICASSO, GINO; DEL PILAR TABOADA SOTOMAYOR, MARIA. A Selective Electrochemical Sensor for the Detection of Cd(II) Based on a Carbon Paste Electrode Impregnated with a Novel Ion-imprinted Hybrid Polymer. Electroanalysis, v. 33, n. 6, MAR 2021. (19/00677-7, 14/50945-4)

ZEB, SHAKEEL; VILLA, JAVIER E. L.; WONG, ADEMAR; KHAN, SABIR; HUSSAIN, SAJJAD; SOTOMAYOR, MARIA D. P. T.. Combining Fluorescent Quantum Dots with Molecularly Imprinted Polymers for the Screening of both Emerging and Classical Environmental Pollutants: A Review. Journal of the Brazilian Chemical Society, v. N/A, p. 26-pg., 2023-01-25. (17/24196-2, 14/50945-4, 19/00677-7)

PUPIN, RAFAEL ROVATTI; TABOADA SOTOMAYOR, MARIA DEL PILAR. Synthesis and evaluation of hollow porous molecularly imprinted polymer for selective determination of tetracycline. Journal of Materials Science, v. 57, n. 36, p. 13-pg., 2022-09-17. (14/50945-4, 19/00677-7, 17/20789-9)