caling laws and the left main coronary artery bifurcation. A combination of geometric and simulation analyse

Author(s)

Blanco, Pablo J. ^{[1, 2]} ; Vargas dos Santos, Gabriela H. ^[3] ; Bulant, Carlos A. ^{[2, 4, 5]} ; Alvarez, Alonso M. ^{[1, 2]} ; Oliveira, Fredric A. P. ^[3] ; Cunha-Lima, Gabriella ^[3] ; Lemos, Pedro A. ^{[3, 2, 6, 7]}

Affiliation

^[1] Natl Lab Sci Comp, Av Getulio Vargas 333, BR-25651075 Petropolis, RJ - Brazil

^[2] Natl Inst Sci & Technol Med Assisted Sci Comp, Petropolis, RJ - Brazil

^[3] Hosp Israelita Albert Einstein, Sao Paulo - Brazil

^[4] Consejo Nacl Invest Cient & Tecn, Natl Sci & Tech Res Council, Tandil - Argentina

^[5] Natl Univ Ctr, Tandil - Argentina

^[6] Heart Inst InCor, Dept Intervent Cardiol, BR-05403904 Sao Paulo - Brazil

^[7] Univ Sao Paulo, Med Sch, BR-05403904 Sao Paulo - Brazil

• Document type: Journal article
• Source: MEDICAL ENGINEERING & PHYSICS; v. 99, JAN 2022.
• Web of Science Citations: 0

Abstract

The geometry of coronary arteries is believed to play the role as an atherosclerotic risk factor on its own. The full characterization of the normal coronary network has been reported in the literature. Reports on the integration of geometry and functional data for normal coronary vessels started to proliferate more recently. In this work, we analyze and integrate the geometric data retrieved from angiography images of the left main coronary bifurcation in angiographically normal patients and hemodynamic data generated from blood flow models to analyze the role of allometric laws and the connection between flow distribution and wall shear stress loads on the left anterior descending and left circumflex arteries. This in-silico study contributes to the characterization of normal coronary anatomy and its impact on the hemodynamic shear stresses acting over the vessel wall, shedding light on the impact of geometry-based versus simulation-based hypotheses to define boundary conditions for numerical simulations. We discuss the role of the wall shear stress corresponding to scenarios adopted by the scientific community and the ones proposed in this study. For the simulation-based hypothesis, we propose an iterative strategy to define boundary conditions at the main left coronary bifurcation, such that wall shear stresses are matched between the left descending and left circumflex arteries. From this study, we conclude that a one-fits-all power law exponent of 7/3 results in an good trade-off between computational cost and wall shear stress balance between daughter vessels. (AU)

• FAPESP's process: 18/14221-2 - Coronary bifurcations geometry: an exploratory study of the mathematical laws to estimate the vascular dimensions in coronary bifurcations
• Grantee: Gabriela Hidalgo Vargas dos Santos
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 14/50889-7 - National Institute of Science and Technology Medicine Assisted by Scientific Computing (INCT-MACC)
• Grantee: José Eduardo Krieger
• Support Opportunities: Research Projects - Thematic Grants