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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

onoketonic Curcuminoid-Lidocaine Co-Deliver Using Thermosensitive Organogels: From Drug Synthesis to Epidermis Structural Studie

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Author(s):
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Vigato, Aryane A. [1] ; Machado, Ian P. [2] ; del Valle, Matheus [3] ; da Ana, Patricia A. [3] ; Sepulveda, Anderson F. [1] ; Yokaichiya, Fabiano [4] ; Franco, Margareth K. K. D. [5] ; Loiola, Messias C. [1] ; Tofoli, Giovana R. [6] ; Cereda, Cintia Maria S. [6] ; de Sairre, Mirela I. [1] ; de Araujo, Daniele R. [1]
Total Authors: 12
Affiliation:
[1] Fed Univ ABC, Human & Nat Sci Ctr, BR-09210580 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, BR-05508000 Sao Paulo, SP - Brazil
[3] Fed Univ ABC, Ctr Engn Modeling & Appl Social Sci, BR-09606045 Sao Bernardo, SP - Brazil
[4] Helmholtz Zentrum Berlin Mat, Dept Quantum Phenomena Novel Mat, D-14109 Berlin - Germany
[5] Nucl & Energy Res Inst, BR-01000000 Sao Paulo, SP - Brazil
[6] Sao Leopoldo Mandic Res Unit, BR-13000000 Campinas, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: HARMACEUTIC; v. 14, n. 2 FEB 2022.
Web of Science Citations: 0
Abstract

Organogels (ORGs) are remarkable matrices due to their versatile chemical composition and straightforward preparation. This study proposes the development of ORGs as dual drug-carrier systems, considering the application of synthetic monoketonic curcuminoid (m-CUR) and lidocaine (LDC) to treat topical inflammatory lesions. The monoketone curcuminoid (m-CUR) was synthesized by using an innovative method via a NbCl5-acid catalysis. ORGs were prepared by associating an aqueous phase composed of Pluronic F127 and LDC hydrochloride with an organic phase comprising isopropyl myristate (IPM), soy lecithin (LEC), and the synthesized m-CUR. Physicochemical characterization was performed to evaluate the influence of the organic phase on the ORGs supramolecular organization, permeation profiles, cytotoxicity, and epidermis structural characteristics. The physico-chemical properties of the ORGs were shown to be strongly dependent on the oil phase constitution. Results revealed that the incorporation of LEC and m-CUR shifted the sol-gel transition temperature, and that the addition of LDC enhanced the rheological G `/G `' ratio to higher values compared to original ORGs. Consequently, highly structured gels lead to gradual and controlled LDC permeation profiles from the ORG formulations. Porcine ear skin epidermis was treated with ORGs and evaluated by infrared spectroscopy (FTIR), where the stratum corneum lipids were shown to transition from a hexagonal to a liquid crystal phase. Quantitative optical coherence tomography (OCT) analysis revealed that LEC and m-CUR additives modify skin structuring. Data from this study pointed ORGs as promising formulations for skin-delivery. (AU)

FAPESP's process: 19/20303-4 - Thermosensitive organogels as strategies for the treatment of inflammatory processes: from supramolecular structure to pharmacological evaluation
Grantee:Daniele Ribeiro de Araujo
Support Opportunities: Regular Research Grants
FAPESP's process: 16/18045-9 - Study of Hantzsch multicomponent reaction for the synthesis of new dipeptidyl peptidase 4 (DPP-4) inhibitors for treatment of type II Diabetes
Grantee:Mirela Inês de Sairre
Support Opportunities: Regular Research Grants
FAPESP's process: 19/14773-8 - Organogels lecitin-poloxamer-based for skin delivery: development, ex vivo permeation profile and stratum corneum structural evaluation
Grantee:Aryane Alves Vigato
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)