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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epigenetic studies in insects and the valproic acid perspective

Full text
Author(s):
D. S. Santos [1] ; M. A. Rocha [2] ; M. L. S. Mello [3]
Total Authors: 3
Affiliation:
[1] Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Biologia Estrutural e Funcional - Brasil
[2] Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Biologia Estrutural e Funcional - Brasil
[3] Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Biologia Estrutural e Funcional - Brasil
Total Affiliations: 3
Document type: Journal article
Source: Brazilian Journal of Biology; v. 84, 2022-04-08.
Abstract

Abstract Valproic acid in association with sodium valproate (VPA) is an important anticonvulsant drug used for decades to treat neurological disorders. VPA also acts as an epigenetic modulator by inhibiting histone deacetylases, permitting histone acetylation, affecting the DNA and histone methylation status and gene expression, and inducing chromatin remodeling. Insects represent an important animal model for studies in several areas of science. Their high phenotypic plasticity makes them alternative models for epigenetic studies. This brief review emphasizes recent reports on insect epigenetics and the contribution of studies on the VPA action in insects, including effects on epigenetic markers, extending the pharmacological understanding of the potential of this drug, and demonstrating the usefulness of insects as an alternative animal model to drug studies. (AU)

FAPESP's process: 18/07888-0 - Effects of the valproic acid (VPA) on the chromatin of Malpighian tubules of Triatoma infestans under in vitro conditions
Grantee:Alessandra Bassani
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/10356-2 - Action of valproic acid on chromatin structure and function
Grantee:Maria Luiza Silveira Mello
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 19/20833-3 - Epigenetic markers responsive to sodium valproate in the heterocrhomatin of Triatoma infestans (Klug)
Grantee:Douglas Silva dos Santos
Support Opportunities: Scholarships in Brazil - Post-Doctoral