Neck circumference as a predictor of gestational diabetes and risk of adverse outcomes in pregnancy of Brazilian woman with overweight and obesity

Author(s)

Camila Rodrigues de Souza Carvalho ^[1] ; Patricia Medici Dualib ; Rosiane Mattar ^[3] ; Sérgio Atala Dib ; Bianca de Almeida-Pititto

Affiliation

^[1] Universidade Federal de São Paulo. Programa de Pós-graduação em Endocrinologia e Metabologia - Brasil

^[3] Universidade Federal de São Paulo. Departamento de Obstetrícia - Brasil

• Document type: Journal article
• Source: ARCHIVES OF ENDOCRINOLOGY METABOLISM; 2022-06-10.

Abstract

ABSTRACT Objective: To evaluate the association of neck circumference (NC) with gestational diabetes (GDM) and adverse outcomes in women with overweight and obesity. Subjects and methods: This prospective study included 132 (BMI > 25 kg/m2) pregnant women without and with GDM. Standardized questionnaire and biochemical/physical evaluation were performed during the 1st to 3rd trimester. Fifth-five women were evaluated regarding hypertension in pregnancy, type of delivery and neonatal complications (death, intensive care unit admission and hypoglycemia). Results: Women with (n = 61) and without (n = 71) GDM had similar mean (SD) pre-gestational BMI [30.3 (4.0) vs. 29.4 (3.5) kg/m2, p = 0.16]. Women with GDM were older [32 (6) vs. 28 (6) yrs, p < 0.001] and had greater NC [36.0 (2.7) vs. 34.5 (1.8) cm, p < 0.001]. NC was similar in women with GDM diagnosed in first or third trimester [p = 0.4] and was correlated with FPG [r 0.29, p = 0.01] and systolic [r 0.28, p = 0.001] and diastolic [r 0.25, p = 0.004] blood pressure. NC was associated with GDM [OR 1.25, 95%CI 1.03-1.52] adjusted for age, physical activity, education and familiar history of diabetes. In ROC analysis, the area under the curve was 0.655 and the cut-off value of 34.5 cm had 0.70 of sensitivity and 0.51 of specificity for GDM. Women who had NC ≥ 34.5 vs. < 34.5 cm had higher frequencies of hypertension [32.3 vs. 4.2%, p = 0.01]. Conclusions: In a group of pregnant women with overweight or obesity, NC can be a useful tool for identifying risk of GDM and obstetric adverse outcomes. (AU)

• FAPESP's process: 10/00074-6 - Non-traditional cardiometabolic risk factors on the spectrum of metabolic syndrome in ELSA - São Paulo
• Grantee: Bianca de Almeida Pititto
• Support Opportunities: Scholarships in Brazil - Post-Doctoral