| Full text | |
| Author(s): |
Mendes, Luis Felipe S.
;
Costa-Filho, Antonio J.
Total Authors: 2
|
| Document type: | Journal article |
| Source: | FEBS Letters; v. 596, n. 8, p. 18-pg., 2022-02-14. |
| Abstract | |
The classical secretory pathway is the key membrane-based delivery system in eukaryotic cells. Several families of proteins involved in the secretory pathway, with functionalities going from cargo sorting receptors to the maintenance and dynamics of secretory organelles, share soluble globular domains predicted to mediate protein-protein interactions. One of them is the 'Golgi Dynamics' (GOLD) domain, named after its strong association with the Golgi apparatus. There are many GOLD-containing protein families, such as the transmembrane emp24 domain-containing proteins (TMED/p24 family), animal SEC14-like proteins, human Golgi resident protein ACBD3, a splice variant of TICAM2 called TRAM with GOLD domain, and FYCO1. Here, we critically review the state-of-the-art knowledge of the structures and functions of the main representatives of GOLD-containing proteins in vertebrates. We provide the first unified description of the GOLD domain structure across different families since the first high-resolution structure was determined. With a brand-new update on the definition of the GOLD domain, we also discuss how its tertiary structure fits the beta-sandwich-like fold map and give exciting new directions for forthcoming studies. (AU) | |
| FAPESP's process: | 17/24669-8 - Unraveling the molecular bases of the early protein secretory pathway in humans using biophysical techniques |
| Grantee: | Luis Felipe Santos Mendes |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 20/15542-7 - Design and characterization of micro-reactors constituted by the protein chlorocatechol 1,2-dioxygenase and low complexity domains |
| Grantee: | Antonio José da Costa Filho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/50366-7 - Resolving mechanistic details of peptide transport across membranes using crystallographic and non-crystallographic structural biology approaches |
| Grantee: | Antonio José da Costa Filho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 21/10465-7 - Exploring the dynamic assembly/disassembly of a Golgi matrix protein under stress-conditions |
| Grantee: | Luis Felipe Santos Mendes |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |