Fever as an evolutionary agent to select immune complexes interfaces

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Author(s):	Tofan, Vlad ; Lenghel, Alina ; de Camargo, Maristela Martins ; Stan, Razvan Costin Total Authors: 4
Document type:	Journal article
Source:	IMMUNOGENETICS; v. N/A, p. 10-pg., 2022-05-11.
Abstract
We herein analyzed all available protein-protein interfaces of the immune complexes from the Protein Data Bank whose antigens belong to pathogens or cancers that are modulated by fever in mammalian hosts. We also included, for comparison, protein interfaces from immune complexes that are not significantly modulated by the fever response. We highlight the distribution of amino acids at these viral, bacterial, protozoan and cancer epitopes, and at their corresponding paratopes that belong strictly to monoclonal antibodies. We identify the "hotspots", i.e. residues that are highly connected at such interfaces, and assess the structural, kinetic and thermodynamic parameters responsible for complex formation. We argue for an evolutionary pressure for the types of residues at these protein interfaces that may explain the role of fever as a selective force for optimizing antibody binding to antigens. (AU)

FAPESP's process:	20/06438-1 - Composition of immunoglobulin CDRs: geography and co-evolution with fever-inducing pathogens
Grantee:	Maristela Martins de Camargo
Support Opportunities:	Regular Research Grants