Clearance of Persistent SARS-CoV-2 RNA Detection in a NF kappa B-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report

Author(s):Show less -

Sabino, Janine S. ; Amorim, Mariene R. ; de Souza, William M. ; Marega, Lia F. ; Mofatto, Luciana S. ; Toledo-Teixeira, Daniel A. ; Forato, Julia ; Stabeli, Rodrigo G. ; Costa, Maria Laura ; Spilki, Fernando R. ; Sabino, Ester C. ; Faria, Nuno R. ; Benites, Bruno D. ; Addas-Carvalho, Marcelo ; Stucchi, Raquel S. B. ; Vasconcelos, Dewton M. ; Weaver, Scott C. ; Granja, Fabiana ; Proenca-Modena, Jose Luiz ; Vilela, Maria Marluce dos S.

• Document type: Journal article
• Source: Viruses-Basel; v. 14, n. 5, p. 10-pg., 2022-05-01.

Abstract

Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NF kappa B-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients. (AU)

• FAPESP's process: 20/04558-0 - Characterization of intrinsic risk factors and the development of new diagnostic and treatment alternatives for COVID-19
• Grantee: José Luiz Proença Módena
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/14389-0 - Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE)
• Grantee: Ester Cerdeira Sabino
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/00194-8 - Pathogenesis and neurovirulence of emerging viruses in Brazil
• Grantee: José Luiz Proença Módena
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 18/14372-0 - SPIICA - the São Paulo-Imperial College (UK) Immune Correlates in Arbovirus Infection Network: special emphasis on CHIKV
• Grantee: Rodrigo Guerino Stabeli
• Support Opportunities: Research Projects - Thematic Grants