| Full text | |
| Author(s): |
Scarini, Joao Figurira
;
Almeida Mariz, Bruno Augesto Linhares
;
de Lima-Souza, Reydson Alcides
;
Lavareze, Luccas
;
Emerick, Carolina
;
Tincani, Alfio Jose
;
Abu Egal, Erika Said
;
Altemani, Albina
;
Mariano, Fernanda Vivane
Total Authors: 9
|
| Document type: | Journal article |
| Source: | Oral Oncology; v. 125, p. 3-pg., 2022-02-01. |
| Abstract | |
Introduction: Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma, is a rare variant of squamous cell carcinoma (SCC) that has a variable proportion of carcinomatous and sarcomatous components. Here, we reported an immunohistochemical study of a spindle cell carcinoma with a challenging morphological diagnosis. Case report: A 50-year-old woman with a previous history of nodular melanoma was referred for evaluation of a painful papule in the lower lip. After surgical resection, neoplastic cells showed focal positivity for CK-14, alpha SMA, p63, and confirmed the strong positivity for S100 and vimentin. Tumor cells were negative for HMB-45, Melan A, SOX-10, AE1/AE3, 34 beta E12, CK5-6, CAM5.2, EMA, desmin, calponin, CD10, CD34, and CD68. With these findings, a diagnosis of SpCC was rendered. The patient presented lung and dorsal metastases after 12 months and after 3 years of follow-up, the patient died.Conclusion: In summary, a careful correlation of microscopy and immunohistochemical characteristics is required for the proper diagnosis of this lesion. (AU) | |
| FAPESP's process: | 19/06809-2 - Analysis of mass spectrometry in the malignant transformation of the pleomorphic adenoma. correlation of data with gene expression and exome |
| Grantee: | Reydson Alcides de Lima Souza |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry |
| Grantee: | Fernanda Viviane Mariano Brum Corrêa |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 19/09419-0 - Genomic alterations in the malignant transformation of the Pleomorphic Adenoma |
| Grantee: | João Figueira Scarini |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/24715-2 - FGF-2, FGFR-1, PI3K, Akt and COX-2 expression in Oral Leucoplakia, primary and metastatic Oral Squamous Cell Carcinoma |
| Grantee: | Bruno Augusto Linhares Almeida Mariz |
| Support Opportunities: | Scholarships in Brazil - Doctorate |