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Transdermal permeation of curcumin promoted by choline geranate ionic liquid: Potential for the treatment of skin diseases

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Author(s):
Boscariol, Rodrigo ; Oliveira Junior, Jose M. ; Baldo, Denicezar A. ; Balcao, Victor M. ; Vila, Marta M. D. C.
Total Authors: 5
Document type: Journal article
Source: SAUDI PHARMACEUTICAL JOURNAL; v. 30, n. 4, p. 16-pg., 2022-04-01.
Abstract

The transdermal permeation of curcumin aided by choline and geranic acid ionic liquid (CAGE-IL) was addressed as a potential treatment for skin diseases. An in-depth analysis of the effect of CAGE-IL concentration in the enhancement of transdermal permeation of curcumin was performed, and the results were modelled via nonlinear regression analysis. The results obtained showed that a low percentage of CAGEIL (viz. 2.0%, w/w) was effective in disrupting the skin structure in a transient fashion, facilitating the passage of curcumin dissolved in it.(c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). (AU)

FAPESP's process: 16/12234-4 - TransAppIL - Transdermal delivery of structurally and functionally stabilized protein entities applying ionic liquids.
Grantee:Marta Maria Duarte Carvalho Vila
Support Opportunities: Regular Research Grants
FAPESP's process: 18/05522-9 - PsaPhageKill - isolation, characterisation and use of lytic bacteriophages against Pseudomonas syringae PV. actinidiae to fight the cancer of kiwifruit: an efficient and ecofriendly alternative
Grantee:Vitor Manuel Cardoso Figueiredo Balcão
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 16/08884-3 - PneumoPhageColor - development of a colorimetric biodetection kit for Pseudomonas aeruginosa based on phage particles
Grantee:Vitor Manuel Cardoso Figueiredo Balcão
Support Opportunities: Regular Research Grants