| Full text | |
| Author(s): |
Souza Bomfim, Guilherme Henrique
;
Musial, Diego Castro
;
Rocha, Katiucha
;
Jurkiewicz, Aron
;
Jurkiewicz, Neide Hyppolito
Total Authors: 5
|
| Document type: | Journal article |
| Source: | CLINICAL AND EXPERIMENTAL HYPERTENSION; v. N/A, p. 12-pg., 2022-06-15. |
| Abstract | |
Hypertension and diabetes development had been characterized as idiopathic disorders tightly interconnected, and therefore it is essential to understand how the functionality of neurohormonal pathways are involved in both diseases. Hypertensive and diabetic patients have shown increased systolic blood pressure (SBP), oxidative stress, vascular hypertrophy, and remodeling. It is well established that the long-term consumption of red wine and/or polyphenol-stilbene causes cardioprotective and antihypertensive effects; however, some functions remain unrevealed. Downstream pathways such as reactive oxygen species (ROS), sympathoadrenal axis represented by beta(1)-adrenoceptors, and renin-angiotensin system via angiotensin-II receptors critically contribute to hypertension development. Aims This raised the issue of whether in vivo long-term red wine treatment can act as a modulator of these targets. Main methods We monitored SBP, glucose tolerance, oxidative stress, and cardiovascular function. Aortic and atrial tissues from normotensive-WKY, hypertensive-SHR, and diabetic-STZ animals, chronically exposed to red wine (3.715 ml/kg/v.o/day) or alcohol (12%) for 21-days, were used to measure contractile/relaxation responses by force transducers. Key findings: red wine, but not alcohol, prevented the increase of SBP and hyperglycemic peak. Additionally, was observed prevention of oxidative stress metabolites formation and an improvement in ROS scavenging antioxidant capacity of SHR. We also revealed that red wine intake enhances the endothelium-dependent relaxation, decreases the hypercontractile mediated by angiotensin-II in the aorta, and via beta(1)-adrenoceptors in the atrium. Significance The long-term consumption of red wine can improve oxidative stress and the functionality of angiotensin-II and beta(1)-adrenoceptors, inspiring new pharmacologic and dietetic therapeutic approaches for the treatment of hypertension and diabetes. ACh = Acetylcholine; ANG II = Angiotensin II; AT1 = ANG II type 1 receptor; AUC = Area Under the Curve; Ca2+ = Calcium; Endo + = Endothelium Intact; Fen = Phenylephrine (1 mu M); GTT = Glucose Tolerance Test; ISO = Isoprenaline (isoproterenol); KHN = Krebs-Henseleit Nutrient; LA = Left Atria; LH = Lipid Hydroperoxide; NO = Nitric Oxide; RA = Right Atria; RAS = Renin-Angiotensin System; ROS = Reactive Oxygen Species; SBP = Systolic Blood Pressure; SHR = Spontaneously Hypertensive Rats; STZ = Streptozotocin; WKY = Normotensive Wistar Kyoto Rats. (AU) | |
| FAPESP's process: | 14/01569-0 - Interference of drugs producing disturbances in the drug-receptor interactions in hypertension, hyperglycemia and neurotransmission emphasizing the modulator role of histamine |
| Grantee: | Neide Hyppolito Jurkiewicz |
| Support Opportunities: | Regular Research Grants |