| Full text | |
| Author(s): |
de Souza, Aline A. N.
;
Bartolomeu, Aloisio de A.
;
Brocksom, Timothy J.
;
Noel, Timothy
;
de Oliveira, Kleber T.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | Journal of Organic Chemistry; v. 87, n. 9, p. 10-pg., 2022-05-06. |
| Abstract | |
We investigated the electrochemical sulfenylationreaction in both batch and continuousflow regimes, involvingthiophenols/thiols and enol-acetates to yield alpha-sulfenylatedketones, without using additional oxidants or catalysts. Studieswith different electrolytes were also performed, revealing thatquaternary ammonium salts are the best mediators for this reaction.Notably, during the study of the reaction scope, a Boc-cysteineproved to be extremely tolerant to our protocol, thus increasing itsrelevance. The methodology also proved to be scalable in bothbatch and continuousflow conditions, opening up possibilities forfurther studies since these relevant functional groups are important moieties in organic synthesis (AU) | |
| FAPESP's process: | 15/11801-0 - Development of flow chemistry synthetic platform to obtain molecules of pharmaceutical interest |
| Grantee: | Leandro de Carvalho Alves |
| Support Opportunities: | Research Grants - Innovative Research in Small Business - PIPE |
| FAPESP's process: | 19/27176-8 - Asymmetric photocatalysis applied to the synthesis of Brivaracetam: synthetic approaches employing enabling technologies for chemical synthesis |
| Grantee: | Kleber Thiago de Oliveira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/07276-1 - CEPOF - Optics and Photonic Research Center |
| Grantee: | Vanderlei Salvador Bagnato |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 20/06874-6 - Applications of technologies and synthetic methodologies developed under continuous flow conditions at LQBO-UFSCar for the preparation of molecules with biological activities and APIs |
| Grantee: | Kleber Thiago de Oliveira |
| Support Opportunities: | Regular Research Grants |