| Full text | |
| Author(s): Show less - |
D'Angelo, Natalia A.
;
Noronha, Mariana A.
;
Camara, Mayra C. C.
;
Kurnik, Isabelle S.
;
Feng, Chuying
;
Araujo, Victor H. S.
;
Santos, Joao H. P. M.
;
Feitosa, Valker
;
V.d. Molino, Joao
;
Rangel-Yagui, Carlota O.
;
Chorilli, Marlus
;
Ho, Emmanuel A.
;
Lopes, Andre M.
Total Authors: 13
|
| Document type: | Journal article |
| Source: | BIOMATERIALS ADVANCES; v. 133, p. 23-pg., 2022-02-01. |
| Abstract | |
Doxorubicin (DOX) is a natural antibiotic with antineoplastic activity. It has been used for over 40 years and remains one of the most used drugs in chemotherapy for a variety of cancers. However, cardiotoxicity limits its use for long periods. To overcome this limitation, encapsulation in smart drug delivery systems (DDS) brings advantages in comparison with free drug administration (i.e., conventional anticancer drug therapy). In this review, we present the most relevant nanostructures used for DOX encapsulation over the last 10 years, such as liposomes, micelles and polymeric vesicles (i.e., polymersomes), micro/nanoemulsions, different types of polymeric nanoparticles and hydrogel nanoparticles, as well as novel approaches for DOX encapsulation. The studies highlighted here show these nanoformulations achieved higher solubility, improved tumor cytotoxicity, prolonged DOX release, as well as reduced side effects, among other interesting advantages. (AU) | |
| FAPESP's process: | 18/10799-0 - Combinatorial therapy using polymersomes decorated with transferrin and incorporated into chitosan hydrogels as smart drug delivery systems for melanoma tumor cells |
| Grantee: | André Moreni Lopes |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 18/25994-2 - Development of novel platforms for PEGylation of proteins with therapeutic potential using microfluidics |
| Grantee: | João Henrique Picado Madalena Santos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/10789-1 - Combinatorial therapy using polymersomes decorated with transferrin and incorporated into chitosan hydrogels as smart drug delivery systems for melanoma tumor cells. |
| Grantee: | André Moreni Lopes |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 20/03727-2 - Polymersomes development aiming at the co-encapsulation of drugs for application in cancer therapy |
| Grantee: | Natalia Aimee D'Angelo |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 19/08549-8 - Polymersomes decorated with transferrin and evaluation of their stability and drug release behavior |
| Grantee: | Mayra Caroline Cunha Câmara |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |