| Full text | |
| Author(s): |
Palmeira, Ondina
;
Matos, Larissa R. B.
;
Naslavsky, Michel S.
;
Bueno, Heloisa M. S.
;
Soler, Julia P.
;
Setubal, Joao C.
;
Zatz, Mayana
Total Authors: 7
|
| Document type: | Journal article |
| Source: | ISCIENCE; v. 25, n. 3, p. 19-pg., 2022-03-18. |
| Abstract | |
The question of whether host genetics plays a role in the development of the infant gut microbiota does not, as yet, have a dear answer. In order to throw additional light on this question, we have analyzed 16S rRNA amplicon sequences from 99 valid fecal samples of five sets of dichorionic triplet babies born by C-section from 1 to 36 months of age. Beta diversity analysis showed that monozygotic twins were more similar to each other than their dizygotic siblings. Monozygotic twins also tended to share more amplicon sequence variants between them. Heritability analysis showed that the genera Bacteroides and Veillonella are particularly susceptible to host genetics. We conclude that infant gut microbiota development is influenced by host genetics, but this effect is subtle and may affect only certain bacterial taxa during a limited time period early in life. (AU) | |
| FAPESP's process: | 14/50931-3 - Aging and genetic disorders: genomics and metagenomics |
| Grantee: | Mayana Zatz |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 13/08028-1 - CEGH-CEL - Human Genome and Stem Cell Research Center |
| Grantee: | Mayana Zatz |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |