Intracranial compliance in type 2 diabetes mellitus and its relationship with the cardiovascular autonomic nervous control

Author(s)

G.A.M. Galdino ^[1] ; S.C.G. Moura-Tonello ^[2] ; S.N. Linares ^[3] ; J.C. Milan-Mattos ^[4] ; D.L. Spavieri Jr. ^[5] ; S.M. Oliveira ; A. Porta ; T. Beltrame ; A.M. Catai ^[9]

Affiliation

^[1] Universidade Federal de São Carlos. Departamento de Fisioterapia. Laboratório de Fisioterapia Cardiovascular - Brasil

^[2] Universidade Federal de São Carlos. Departamento de Fisioterapia. Laboratório de Fisioterapia Cardiovascular - Brasil

^[3] Universidade Federal de São Carlos. Departamento de Fisioterapia. Laboratório de Fisioterapia Cardiovascular - Brasil

^[4] Universidade Federal de São Carlos. Departamento de Fisioterapia. Laboratório de Fisioterapia Cardiovascular - Brasil

^[5] Divisão de Ciência de Dados, brain4care - Brasil

^[9] Universidade Federal de São Carlos. Departamento de Fisioterapia. Laboratório de Fisioterapia Cardiovascular - Brasil

• Document type: Journal article
• Source: Brazilian Journal of Medical and Biological Research; v. 55, 2022-09-12.

Abstract

The intracranial compliance in type 2 diabetes mellitus (T2DM) patients and the association with cardiovascular autonomic control have not been fully elucidated. The aim of this study was to assess intracranial compliance using the noninvasive intracranial pressure (niICP) and the monitoring of waveform peaks (P1, P2, and P3) and the relationship with cardiovascular autonomic control in T2DM patients. Thirty-two men aged 40-60 years without cardiovascular autonomic neuropathy (CAN) were studied: T2DMG (n=16) and control group CG (n=16). The niICP was evaluated by a noninvasive extracranial sensor placed on the scalp. Cardiovascular autonomic control was evaluated by indices of the baroreflex sensitivity (BRS), from temporal series of R-R intervals of electrocardiogram and systolic arterial pressure, during supine and orthostatic positions. The participants remained in the supine position for 15 min and then 15 min more in orthostatism. T2DMG presented a decrease of the P2/P1 ratio during the orthostatic position (P<0.001). There was a negative moderate correlation between the P2 peak with cardiovascular coupling (K2HP-SAPLF) in supine (r=-0.612, P=0.011) and orthostatic (r=-0.568, P=0.020) positions in T2DMG. We concluded that T2DM patients without CAN and cardiovascular complications presented intracranial compliance similar to healthy subjects. Despite preserved intracranial adjustments, T2DM patients had a response of greater magnitude in orthostatism. In addition, the decoupling between the heart period and blood pressure signal oscillations in low frequency appeared to be related to the worsening of intracranial compliance due to the increased P2 peak. (AU)

• FAPESP's process: 17/09639-5 - Exploring machine learning techniques for aerobic system analysis with applicability for cardiorespiratory rehabilitation programs
• Grantee: Thomas Beltrame
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 10/52070-4 - New approaches for evaluation of cardiovascular oscillations changes with aging
• Grantee: Aparecida Maria Catai
• Support Opportunities: Regular Research Grants