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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Endometrial receptivity in cattle: the mutual reprogramming paradigm

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Author(s):
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Mario Binelli [1] ; Felipe Alves Correa Carvalho Silva [2] ; Cecilia Constantino Rocha [3] ; Thiago Martins [4] ; Mariana Sponchiado [5] ; Veerle Van Hoeck [6] ; Andrey Cordeiro [7] ; Meghan Campbell [8] ; Jo L. M. R. Leroy [9] ; Francisco Peñagaricano [10] ; Guilherme Pugliesi [11]
Total Authors: 11
Affiliation:
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[1] University of Florida. Department of Animal Sciences - Estados Unidos
[2] University of Florida. Department of Animal Sciences - Estados Unidos
[3] University of Florida. Department of Animal Sciences - Estados Unidos
[4] Mississippi State University. Department of Animal and Dairy Sciences and Brown Loam Experiment Station - Estados Unidos
[5] University of Florida, Gainesville. College of Veterinary Medicine. Department of Physiological Sciences - Estados Unidos
[6] Animal Nutrition and Health EMENA. Kemin Europa - Bélgica
[7] Universidade Federal do Acre. Centro de Ciências Biológicas e da Natureza - Brasil
[8] University of Florida. Department of Animal Sciences - Estados Unidos
[9] University of Antwerp. Gamete Research Centre. Department of Veterinary Sciences - Bélgica
[10] University of Wisconsin-Madison. Department of Animal and Dairy Sciences - Estados Unidos
[11] Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Reprodução Animal - Brasil
Total Affiliations: 11
Document type: Journal article
Source: Animal Reproduction; v. 19, n. 4 2022-12-16.
Abstract

Abstract Prior to implantation in cattle, the mucous medium contained in the uterine lumen serves as a working interface for molecular exchange and signaling between the lining endometrium and the embryo. The composition of this luminal fluid changes temporally according to the secretory and reabsorptive activities of the uterus and the embryo, which are under complex regulation. Via this interface, both the embryo and the endometrium reprogram each other’s functions to support pregnancy continuation beyond the pre-implantation period. More specifically, the embryo receives elongation signals and the uterus receives anti-luteolytic stimuli. Here, characteristics of the luminal compartment as well as the regulation of its composition to determine the pregnancy outcome will be discussed. (AU)

FAPESP's process: 11/03226-4 - Signatures of receptivity
Grantee:Mario Binelli
Support Opportunities: Research Projects - Thematic Grants