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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hydroxymethylnitrofurazone (NFOH) decreases parasitaemia, parasitism and tissue lesion caused by infection with the Bolivia Trypanosoma cruzi type I strain in Swiss and C57BL/6 mice

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Author(s):
Cauê Benito Scarim [1] ; Cleverton Roberto de Andrade [2] ; Rossana Falcone [3] ; Letícia Moreno Ambrozini [4] ; Vitor Izidoro Senhorelli [5] ; João Aristeu da Rosa [6] ; Chung Man Chin [7]
Total Authors: 7
Affiliation:
[1] Sao Paulo State University “Júlio de Mesquita Filho”, UNESP. Faculty of Pharmaceutical Sciences. Department of Pharmaceuticals and Medicines - Brasil
[2] Sao Paulo State University “Júlio de Mesquita Filho”, UNESP. Faculty of Dentistry. Department of Physiology and Pathology - Brasil
[3] Sao Paulo State University “Júlio de Mesquita Filho”, UNESP. Faculty of Pharmaceutical Sciences. Department of biosciences and biotechnology - Brasil
[4] Sao Paulo State University “Júlio de Mesquita Filho”, UNESP. Faculty of Pharmaceutical Sciences. Department of biosciences and biotechnology - Brasil
[5] Sao Paulo State University “Júlio de Mesquita Filho”, UNESP. Faculty of Pharmaceutical Sciences. Department of Pharmaceuticals and Medicines - Brasil
[6] Sao Paulo State University “Júlio de Mesquita Filho”, UNESP. Faculty of Pharmaceutical Sciences. Department of biosciences and biotechnology - Brasil
[7] Sao Paulo State University “Júlio de Mesquita Filho”, UNESP. Faculty of Pharmaceutical Sciences. Department of Pharmaceuticals and Medicines - Brasil
Total Affiliations: 7
Document type: Journal article
Source: Brazilian Journal of Pharmaceutical Sciences; v. 58, 2023-01-09.
Abstract

Abstract The chemical hydroxymethylation of the antimicrobial nitrofurazone leads to the prodrug NFOH, also increases the anti-T. cruzi activities (in vitro and in vivo), as well as showed non-genotoxic (Ames and micronucleus assays). In the present study, we assessed the anti-T. cruzi effect of the NFOH In vivo - in acute Swiss and C57Bl/6 experimental Chagas models. The treatment started at 5 days post-infection during 20 consecutive days (orally, once day, 150mg/kg), and the parasitaemia as well as histopathology analysis were performed. In both experimental murine models, NFOH was able to reduce parasitemia blood avoiding parasitic reactivation, during immunosuppression period (dexamethasone 5mg/kg, 14 days), in 100% of the mice, and decrease tissue parasite nests, demonstrating absence of amastigote forms in all organs (100%) analyzed, data similar to benznidazole (BZN). Therefore, the results shown here pointing to the NFOH as promising compound for further preclinical studies, being a high potential drug to effective and safe chemotherapy to Chagas disease. (AU)

FAPESP's process: 16/10847-9 - Hydroxymethylnitrofurazone (NFOH): activity study in chronic phase of Chagas' Disease in an animal model and synthesis of soluble derivatives
Grantee:Cauê Benito Scarim
Support Opportunities: Scholarships in Brazil - Doctorate