Histone Modifications in Alzheimer's Disease

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Author(s):	Santana, Dalileia Aparecida ; Smith, Marilia de Arruda Cardoso ; Chen, Elizabeth Suchi Total Authors: 3
Document type:	Journal article
Source:	GENES; v. 14, n. 2, p. 18-pg., 2023-02-01.
Abstract
Since Late-onset Alzheimer's disease (LOAD) derives from a combination of genetic variants and environmental factors, epigenetic modifications have been predicted to play a role in the etiopathology of LOAD. Along with DNA methylation, histone modifications have been proposed as the main epigenetic modifications that contribute to the pathologic mechanisms of LOAD; however, little is known about how these mechanisms contribute to the disease's onset or progression. In this review, we highlighted the main histone modifications and their functional role, including histone acetylation, histone methylation, and histone phosphorylation, as well as changes in such histone modifications that occur in the aging process and mainly in Alzheimer's disease (AD). Furthermore, we pointed out the main epigenetic drugs tested for AD treatment, such as those based on histone deacetylase (HDAC) inhibitors. Finally, we remarked on the perspectives around the use of such epigenetics drugs for treating AD. (AU)

FAPESP's process:	16/25562-0 - Gastric cancer molecular and functional approaches in the Brazilian population
Grantee:	Marilia de Arruda Cardoso Smith
Support Opportunities:	Research Projects - Thematic Grants