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Gastric cancer molecular and functional approaches in the Brazilian population

Abstract

Gastric cancer is the third leading cause of cancer death worldwide, besides the reduction in its incidence. Late diagnosis usually occurs due to the absence of symptoms or the presence of non-specific symptoms in early stages of the disease. In this case, the available therapeutic options are not efficient, resulting in high morbidity and mortality rates. The continuous study of new strategies for early diagnosis and identification of new therapeutic methods is of great interest in this disease. Our research group has been conducting studies on gastric cancer for over 15 years, in which different chromosomal, gene, protein, and epigenetic alterations have been identified. The purpose of this project is to deepen and extend our previous studies that have shown promising results, as well as, address new technologies for identifying possible biomarkers in gastric cancer. This project involves the analysis of transcriptional and genetic alterations in 8q24.21, validation of epigenetically modulated genes, molecular and phenotypic effects under overexpression and silencing of PCAF, BMP8B, MALAT1 and YWHAE genes in gastric cell lines, inhibition of MELK in cell lines treated with OTSSP167, the miRNoma investigation in gastric tissue samples and circulating signature of miRNAs and the genetic and epigenetic study of the telomere-telomerase complex. This study will allow a better understanding of etiology and physiopathology of gastric carcinogenesis and the identification of possible biomarkers, which may help in early diagnosis, prognosis and anticancer therapies monitoring. Additionally, these possible biomarkers may become targets in the development of new anticancer therapies. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Study highlights anti-tumor activity of curcumin on stomach cancer 
Articles published in other media outlets (53 total):
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Diário do Poder: Estudo destaca ação da curcumina no combate ao câncer de estômago (22/Apr/2019)
UOL: Estudo destaca ação da curcumina no combate ao câncer de estômago (18/Apr/2019)
Portal Exame: Cúrcuma pode ajudar no combate ao câncer de estômago (18/Apr/2019)
Jornal Fatos & Notícias: Curcumina pode ajudar a combater câncer de estômago (18/Sep/2020)
Ciclo Vivo: Curcumina pode ajudar a combater câncer de estômago (02/Jan/2020)
Sempre Questione: Açafrão pode ajudar a prevenir e combater o câncer de estômago, descobre estudo (19/Aug/2019)
Renegade Tribune (EUA): Curcumin May Help Prevent or Combat Stomach Cancer, Study Finds (17/Aug/2019)
Nexus Newsfeed (Austrália): Curcumin may help prevent or combat stomach cancer (15/Aug/2019)
Health Bytes: Curcumine kan helpen bij het voorkomen of bestrijden van maagkanker (15/Aug/2019)
Dr Leonard Coldwell: Curcumin May Help Prevent Or Combat Stomach Cancer, Study Finds (15/Aug/2019)
Waking Times: Curcumin May Help Prevent Or Combat Stomach Cancer, Study Finds (15/Aug/2019)
Truth Theory (Reino Unido): Curcumin May Help Prevent Or Combat Stomach Cancer, Study Finds (12/Aug/2019)
Santé blog (França): Cancer de l’estomac: Les promesses antitumorales de la curcumine (18/Jun/2019)
AgroAlimentando: Un estudio muestra la acción de la curcumina en el combate contra el cáncer de estómago (29/May/2019)
Projeto Colabora: Cúrcuma contra câncer de estômago (28/May/2019)
Al Día (Cuba): La acción de la curcumina en el combate contra el cáncer de estómago (16/May/2019)
Science and Technology Research News (EUA): Study Highlights Anti-Tumor Activity of Curcumin on Stomach Cancer (15/May/2019)
NCYT Amazings (Espanha): La acción de la curcumina en el combate contra el cáncer de estómago (09/May/2019)
Catalunya Vanguardista (Espanha): La curcumina en el combate contra el cáncer de estómago (08/May/2019)
The London Economic (Reino Unido): Yellow curry spice turmeric could prevent stomach cancer (07/May/2019)
Blog Ser Integral e Funcional: Curcumina e saúde gástrica (07/May/2019)
Recent Research Studies: How to use turmeric for cancer treatment (28/Apr/2019)
Medindia (Índia): Turmeric may Help Combat Stomach Cancer (27/Apr/2019)
Chiropractic Economics (EUA): Curcumin may help prevent or combat stomach cancer (24/Apr/2019)
Medical Xpress (Reino Unido): Study highlights anti-tumor activity of curcumin on stomach cancer (23/Apr/2019)
Ineffable Island (EUA): Anti-Tumor Activity of Curcumin On Stomach Cancer Highlighted in New Study (23/Apr/2019)
News Archives Uk (Reino Unido): A study highlights the anti-tumor activity of curcumin on stomach cancer (23/Apr/2019)
Debug Lies News: Curcumin can help prevent or combat stomach cancer (23/Apr/2019)
Nexus Newsfeed (Austrália): Anti-tumor activity of curcumin on stomach cancer (23/Apr/2019)
Jornal Joseense News: Estudo destaca ação da curcumina no combate ao câncer de estômago (23/Apr/2019)
Alternative Medicine Doctors: Study highlights anti-tumor activity of curcumin on stomach cancer (23/Apr/2019)
Deuxieme (Holanda): Study highlights anti-tumor activity of curcumin on stomach cancer (23/Apr/2019)
About Cancer Service: Study highlights anti-tumor activity of curcumin on stomach cancer (23/Apr/2019)
R&D Magazine (EUA) online: Study highlights anti-tumor activity of curcumin on stomach cancer (22/Apr/2019)
News Medical (Austrália): Study identifies possible therapeutic effects of curcumin on stomach cancer (22/Apr/2019)
ScienceDaily (EUA): Anti-tumor activity of curcumin on stomach cancer (22/Apr/2019)
Bioengineer (Reino Unido): Study highlights anti-tumor activity of curcumin on stomach cancer (22/Apr/2019)
Scienmag Science Magazine (Reino Unido): Study highlights anti-tumor activity of curcumin on stomach cancer (22/Apr/2019)
Brightsurf: Study highlights anti-tumor activity of curcumin on stomach cancer (22/Apr/2019)
Health News Report (EUA): Curcumin prevents stomach cancer (22/Apr/2019)
Hot News in Nigeria: Study highlights anti-tumor activity of curcumin on stomach cancer (22/Apr/2019)
Onties: The study identifies the possible therapeutic effects of curcumin on gastric cancer (22/Apr/2019)
NewsCaf: Anti-tumor activity of curcumin on stomach cancer (22/Apr/2019)
Medicine News Line: Study highlights anti-tumor activity of curcumin on stomach cancer (22/Apr/2019)
Devdiscourse (Índia): Curcumin may prevent stomach cancer, says study (22/Apr/2019)
Agenparl (Itália): Study highlights anti-tumor activity of curcumin on stomach cancer (22/Apr/2019)
7thSpace: Study highlights anti-tumor activity of curcumin on stomach cancer (22/Apr/2019)
Estação Cereal: Estudo destaca ação da curcumina no combate ao câncer de estômago (22/Apr/2019)
Shilfa: The study identified the possible therapeutic effects of curcumin on stomach cancer (22/Apr/2019)
Moneyrf.com: Study highlights anti-tumor activity of curcumin on stomach cancer (22/Apr/2019)
Espaço Ecológico no Ar: Estudo destaca ação da curcumina no combate ao câncer de estômago (18/Apr/2019)
Piaçabuçu News: Estudo destaca ação da curcumina no combate ao câncer de estômago (18/Apr/2019)
Paraná Praia: Curcumina pode ajudar a combater câncer de estômago (02/Jan/2020)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANAUATE, ANA CAROLINA; LEAL, MARIANA FERREIRA; QUEIROZ CALCAGNO, DANIELLE; GIGEK, CAROLINA OLIVEIRA; REAL KARIA, BRUNO TAKAO; WISNIESKI, FERNANDA; DOS SANTOS, LEONARDO CAIRES; CHEN, ELIZABETH SUCHI; BURBANO, ROMMEL RODRIGUEZ; CARDOSO SMITH, MARILIA ARRUDA. The Complex Network between MYC Oncogene and microRNAs in Gastric Cancer: An Overview. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 5 MAR 2020. Web of Science Citations: 0.
CALCAGNO, DANIELLE Q.; WISNIESKI, FERNANDA; DA SILVA MOTA, ELIZANGELA R.; MAIA DE SOUSA, STEFANIE B.; COSTA DA SILVA, JESSICA M.; LEAL, MARIANA F.; GIGEK, CAROLINA O.; SANTOS, LEONARDO C.; RASMUSSEN, LUCAS T.; ASSUMPCAO, PAULO P.; BURBANO, ROMMEL R.; SMITH, MARILIA A. C. Role of histone acetylation in gastric cancer: implications of dietetic compounds and clinical perspectives. Epigenomics, v. 11, n. 3, p. 349-362, FEB 2019. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.