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Gastric cancer molecular and functional approaches in the Brazilian population

Grant number: 16/25562-0
Support type:Research Projects - Thematic Grants
Duration: September 01, 2017 - August 31, 2022
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Marilia de Arruda Cardoso Smith
Grantee:Marilia de Arruda Cardoso Smith
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers:Carolina de Oliveira Gigek ; Danielle Queiroz Calcagno ; Elizabeth Suchi Chen ; Fernanda Wisnieski ; Mariana Ferreira Leal ; Rommel Mario Rodríguez Burbano ; Spencer Luiz Marques Payão
Associated scholarship(s):19/00077-0 - Molecular and phenotypical evaluation of PCAF silencing in gastric cell lines, BP.TT
18/26796-0 - Validation of implicated miRNAs by qRT-PCR in gastric cancer samples, BP.TT
18/18522-7 - Analysis of 8q24.21 microRNAs expression in gastric carcinogenesis, BP.IC

Abstract

Gastric cancer is the third leading cause of cancer death worldwide, besides the reduction in its incidence. Late diagnosis usually occurs due to the absence of symptoms or the presence of non-specific symptoms in early stages of the disease. In this case, the available therapeutic options are not efficient, resulting in high morbidity and mortality rates. The continuous study of new strategies for early diagnosis and identification of new therapeutic methods is of great interest in this disease. Our research group has been conducting studies on gastric cancer for over 15 years, in which different chromosomal, gene, protein, and epigenetic alterations have been identified. The purpose of this project is to deepen and extend our previous studies that have shown promising results, as well as, address new technologies for identifying possible biomarkers in gastric cancer. This project involves the analysis of transcriptional and genetic alterations in 8q24.21, validation of epigenetically modulated genes, molecular and phenotypic effects under overexpression and silencing of PCAF, BMP8B, MALAT1 and YWHAE genes in gastric cell lines, inhibition of MELK in cell lines treated with OTSSP167, the miRNoma investigation in gastric tissue samples and circulating signature of miRNAs and the genetic and epigenetic study of the telomere-telomerase complex. This study will allow a better understanding of etiology and physiopathology of gastric carcinogenesis and the identification of possible biomarkers, which may help in early diagnosis, prognosis and anticancer therapies monitoring. Additionally, these possible biomarkers may become targets in the development of new anticancer therapies. (AU)

Articles published in Agência FAPESP about the research grant
Study highlights anti-tumor activity of curcumin on stomach cancer 
Articles published in other Midia (36 total):
More itemsLess items
Cancer de l’estomac: Les promesses antitumorales de la curcumine 
Un estudio muestra la acción de la curcumina en el combate contra el cáncer de estómago 
Cúrcuma contra câncer de estômago 
La acción de la curcumina en el combate contra el cáncer de estómago 
Study Highlights Anti-Tumor Activity of Curcumin on Stomach Cancer 
La acción de la curcumina en el combate contra el cáncer de estómago 
La curcumina en el combate contra el cáncer de estómago 
Curcumina e saúde gástrica 
Yellow curry spice turmeric could prevent stomach cancer 
Turmeric may Help Combat Stomach Cancer 
Curcumin may help prevent or combat stomach cancer 
Anti-Tumor Activity of Curcumin On Stomach Cancer Highlighted in New Study 
Estudo destaca ação da curcumina no combate ao câncer de estômago 
Anti-tumor activity of curcumin on stomach cancer 
A study highlights the anti-tumor activity of curcumin on stomach cancer 
Study highlights anti-tumor activity of curcumin on stomach cancer 
Curcumin may prevent stomach cancer, says study 
Curcumin prevents stomach cancer 
Study highlights anti-tumor activity of curcumin on stomach cancer 
Study identifies possible therapeutic effects of curcumin on stomach cancer 
Anti-tumor activity of curcumin on stomach cancer 
Study highlights anti-tumor activity of curcumin on stomach cancer 
Study highlights anti-tumor activity of curcumin on stomach cancer 
Study highlights anti-tumor activity of curcumin on stomach cancer 
Estudo destaca ação da curcumina no combate ao câncer de estômago 
The study identifies the possible therapeutic effects of curcumin on gastric cancer 
Study highlights anti-tumor activity of curcumin on stomach cancer 
Anti-tumor activity of curcumin on stomach cancer 
Study highlights anti-tumor activity of curcumin on stomach cancer 
Study highlights anti-tumor activity of curcumin on stomach cancer 
Study highlights anti-tumor activity of curcumin on stomach cancer 
Estudo destaca ação da curcumina no combate ao câncer de estômago 
Estudo destaca ação da curcumina no combate ao câncer de estômago 
Estudo destaca ação da curcumina no combate ao câncer de estômago 
Cúrcuma pode ajudar no combate ao câncer de estômago 
Estudo destaca ação da curcumina no combate ao câncer de estômago 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CALCAGNO, DANIELLE Q.; WISNIESKI, FERNANDA; DA SILVA MOTA, ELIZANGELA R.; MAIA DE SOUSA, STEFANIE B.; COSTA DA SILVA, JESSICA M.; LEAL, MARIANA F.; GIGEK, CAROLINA O.; SANTOS, LEONARDO C.; RASMUSSEN, LUCAS T.; ASSUMPCAO, PAULO P.; BURBANO, ROMMEL R.; SMITH, MARILIA A. C. Role of histone acetylation in gastric cancer: implications of dietetic compounds and clinical perspectives. Epigenomics, v. 11, n. 3, p. 349-362, FEB 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
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