Physical Exercise: A Versatile Anti-Inflammatory Tool Involved in the Control of Hypothalamic Satiety Signaling

Author(s)

Ropelle, Eduardo Rochete ; Ramos da Silva, Adelino Sanchez ; Cintra, Dennys Esper ; de Moura, Leandro Pereira ; Teixeira, Ana Maria ; Pauli, Jose Rodrigo

• Document type: Journal article
• Source: EXERCISE IMMUNOLOGY REVIEW; v. 27, p. 17-pg., 2021-01-01.

Abstract

The hypothalamus plays a critical role in the control of food consumption and energy expenditure. Fatty diets can elicit an inflammatory response in specific hypothalamic cells, including astrocytes, tanycytes, and microglia, disrupting anorexigenic signals in region-specific hypothalamic neurons, contributing to overeating and body weight gain. In this study, we present an update regarding the knowledge of the effects of physical exercise on inflammatory signaling and circuits to control hunger in the hypothalamus in obesity conditions. To try to understand changes in the hypothalamus, we review the use of magnetic resonance/anorexigenic hormone analysis in humans, as well as in animal models to explore the physiological and molecular mechanism by which exercise modulates satiety signals, such as the central antiinflammatory response, myokine delivery from skeletal muscle, and others. The accumulation of scientific evidence in recent years allows us to understand that exercise contributes to weight control, and it is managed by mechanisms that go far beyond "burning calories." (AU)

• FAPESP's process: 19/00227-1 - Effects mediated by the exercise and metformin on rock protein and the regulation of lipogenesis and glucose production in the liver of rodents with celiac disease
• Grantee: José Rodrigo Pauli
• Support Opportunities: Scholarships abroad - Research
• FAPESP's process: 18/20872-6 - Effects of physical exercise on Rock protein signaling pathway, and lipogenic regulation and gluconeogenesis in the liver of aged rats
• Grantee: José Rodrigo Pauli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/07634-9 - Evaluation of mitonuclear imbalance and UPRmt in the skeletal muscle of exercise mice: The role JNK and PKR.
• Grantee: Eduardo Rochete Ropelle
• Support Opportunities: Regular Research Grants