| Full text | |
| Author(s): |
Cardoso, Luana Pereira
;
de Sousa, Stefanie Oliveira
;
Gusson-Zanetoni, Juliana Prado
;
de Melo Moreira Silva, Laura Luciana de Melo Moreira
;
Frigieri, Barbara Maria
;
Henrique, Tiago
;
Tajara, Eloiza Helena
;
Oliani, Sonia Maria
;
Rodrigues-Lisoni, Flavia Cristina
Total Authors: 9
|
| Document type: | Journal article |
| Source: | PHARMACEUTICALS; v. 16, n. 1, p. 21-pg., 2023-01-01. |
| Abstract | |
Cervical cancer is the fourth-most common type of cancer in the world that causes death in women. It is mainly caused by persistent infection by human papillomavirus (HPV) that triggers a chronic inflammatory process. Therefore, the use of anti-inflammatory drugs is a potential treatment option. The effects of piperine, an amino alkaloid derived from Piper nigrum, are poorly understood in cervical cancer inflammation, making it a target of research. This work aimed to investigate the antitumor effect of piperine on cervical cancer and to determine whether this effect is modulated by the cyclooxygenase 2 (PTGS2) pathway using in vitro model of cervical cancer (HeLa, SiHa, CaSki), and non-tumoral (HaCaT) cell lines. The results showed that piperine reduces in vitro parameters associated with neoplastic evolution such as proliferation, viability and migration by cell cycle arrest in the G1/G0 and G2/M phases, with subsequent induction of apoptosis. This action was modulated by downregulation of cyclooxygenase 2 (PTGS2) pathway, which in turn regulates the secretion of cytokines and the expression of mitogen-activated protein kinases (MAPKs), metalloproteinases (MMPs), and their antagonists (TIMPs). These findings indicate the phytotherapeutic potential of piperine as complementary treatment in cervical cancer. (AU) | |
| FAPESP's process: | 17/02100-3 - Piper cubeba: applications in different tumorigenic cell lines |
| Grantee: | Flávia Cristina Rodrigues Lisoni |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/19949-7 - Evaluation of annexin A1 protein immunomodulatory activity in cutaneous and placental lesions resulting from Diabetes Mellitus |
| Grantee: | Sonia Maria Oliani |
| Support Opportunities: | Regular Research Grants |